Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France

ABSTRACT Salmonella genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. A serious threat to public health was revea...

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Autores principales:	Eliette Schultz, Olivier Barraud, Jean-Yves Madec, Marisa Haenni, Axel Cloeckaert, Marie-Cécile Ploy, Benoît Doublet
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Salmonella genomic island 1 integrative mobilizable element integrons multidrug resistance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0c854bedaf92487886b1404066388e5a
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spelling	oai:doaj.org-article:0c854bedaf92487886b1404066388e5a2021-11-15T15:21:46ZMultidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France10.1128/mSphere.00118-172379-5042https://doaj.org/article/0c854bedaf92487886b1404066388e5a2017-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00118-17https://doaj.org/toc/2379-5042ABSTRACT Salmonella genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. A serious threat to public health was revealed in the recent description in P. mirabilis of a SGI1-derivative multidrug resistance island named PGI1 (Proteus genomic island 1) carrying extended-spectrum-β-lactamase (ESBL) and metallo-β-lactamase resistance genes, blaVEB-6 and blaNDM-1, respectively. Here, we report the first description of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical Morganella morganii subsp. morganii strain isolated from a patient in France in 2013. Complete-genome sequencing of the strain revealed SGI1 variant SGI1-L carrying resistance genes dfrA15, floR, tetA(G), blaPSE-1 (now referred to as blaCARB-2), and sul1, conferring resistance to trimethoprim, phenicols, tetracyclines, amoxicillin, and sulfonamides, respectively. The SGI1-L variant was integrated into the usual chromosome-specific integration site at the 3′ end of the trmE gene. Beyond Salmonella enterica and Proteus mirabilis, the SGI1 integrative mobilizable element may thus also disseminate its multidrug resistance phenotype in another genus belonging to the Proteae tribe of the family Enterobacteriaceae. IMPORTANCE Since its initial identification in epidemic multidrug-resistant Salmonella enterica serovar Typhimurium DT104 strains, several SGI1 variants, SGI1 lineages, and SGI1-related elements (SGI2, PGI1, and AGI1) have been described in many bacterial genera (Salmonella, Proteus, Morganella, Vibrio, Shewanella, etc.). They constitute a family of multidrug resistance site-specific integrative elements acquired by horizontal gene transfer, SGI1 being the best-characterized element. The horizontal transfer of SGI1/PGI1 elements into other genera is of public health concern, notably with regard to the spread of critically important resistance genes such as ESBL and carbapenemase genes. The identification of SGI1 in Morganella morganii raises the issue of (i) the potential for SGI1 to emerge in other human pathogens and (ii) its bacterial host range. Further surveillance and research are needed to understand the epidemiology, the spread, and the importance of the members of this SGI1 family of integrative elements in contributing to antibiotic resistance development.Eliette SchultzOlivier BarraudJean-Yves MadecMarisa HaenniAxel CloeckaertMarie-Cécile PloyBenoît DoubletAmerican Society for MicrobiologyarticleSalmonella genomic island 1integrative mobilizable elementintegronsmultidrug resistanceMicrobiologyQR1-502ENmSphere, Vol 2, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Salmonella genomic island 1 integrative mobilizable element integrons multidrug resistance Microbiology QR1-502
spellingShingle	Salmonella genomic island 1 integrative mobilizable element integrons multidrug resistance Microbiology QR1-502 Eliette Schultz Olivier Barraud Jean-Yves Madec Marisa Haenni Axel Cloeckaert Marie-Cécile Ploy Benoît Doublet Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
description	ABSTRACT Salmonella genomic island 1 (SGI1) is a multidrug resistance integrative mobilizable element that harbors a great diversity of antimicrobial resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. A serious threat to public health was revealed in the recent description in P. mirabilis of a SGI1-derivative multidrug resistance island named PGI1 (Proteus genomic island 1) carrying extended-spectrum-β-lactamase (ESBL) and metallo-β-lactamase resistance genes, blaVEB-6 and blaNDM-1, respectively. Here, we report the first description of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical Morganella morganii subsp. morganii strain isolated from a patient in France in 2013. Complete-genome sequencing of the strain revealed SGI1 variant SGI1-L carrying resistance genes dfrA15, floR, tetA(G), blaPSE-1 (now referred to as blaCARB-2), and sul1, conferring resistance to trimethoprim, phenicols, tetracyclines, amoxicillin, and sulfonamides, respectively. The SGI1-L variant was integrated into the usual chromosome-specific integration site at the 3′ end of the trmE gene. Beyond Salmonella enterica and Proteus mirabilis, the SGI1 integrative mobilizable element may thus also disseminate its multidrug resistance phenotype in another genus belonging to the Proteae tribe of the family Enterobacteriaceae. IMPORTANCE Since its initial identification in epidemic multidrug-resistant Salmonella enterica serovar Typhimurium DT104 strains, several SGI1 variants, SGI1 lineages, and SGI1-related elements (SGI2, PGI1, and AGI1) have been described in many bacterial genera (Salmonella, Proteus, Morganella, Vibrio, Shewanella, etc.). They constitute a family of multidrug resistance site-specific integrative elements acquired by horizontal gene transfer, SGI1 being the best-characterized element. The horizontal transfer of SGI1/PGI1 elements into other genera is of public health concern, notably with regard to the spread of critically important resistance genes such as ESBL and carbapenemase genes. The identification of SGI1 in Morganella morganii raises the issue of (i) the potential for SGI1 to emerge in other human pathogens and (ii) its bacterial host range. Further surveillance and research are needed to understand the epidemiology, the spread, and the importance of the members of this SGI1 family of integrative elements in contributing to antibiotic resistance development.
format	article
author	Eliette Schultz Olivier Barraud Jean-Yves Madec Marisa Haenni Axel Cloeckaert Marie-Cécile Ploy Benoît Doublet
author_facet	Eliette Schultz Olivier Barraud Jean-Yves Madec Marisa Haenni Axel Cloeckaert Marie-Cécile Ploy Benoît Doublet
author_sort	Eliette Schultz
title	Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
title_short	Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
title_full	Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
title_fullStr	Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
title_full_unstemmed	Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France
title_sort	multidrug resistance <italic toggle="yes">salmonella</italic> genomic island 1 in a <named-content content-type="genus-species">morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> human clinical isolate from france
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/0c854bedaf92487886b1404066388e5a
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Multidrug Resistance <italic toggle="yes">Salmonella</italic> Genomic Island 1 in a <named-content content-type="genus-species">Morganella morganii</named-content> subsp. <italic toggle="yes">morganii</italic> Human Clinical Isolate from France

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