Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches

Leptospira interrogans is one of the causative agents of human leptospirosis, a zoonotic disease with worldwide distribution. Nowadays, this zoonosis is considered one of the biggest in terms of morbidity and mortality (even considering Dengue, the major arbovirosis affecting humans), having in Bra...

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Autores principales:	Andressa Penedo de Paiva Estrella, Amanda Silva Hecktheuer, Fabienne Antunes Ferreira, Ricardo Ruiz Mazzon
Formato:	article
Lenguaje:	EN ES PT
Publicado:	Universidade Federal de Santa Catarina 2021
Materias:	Leptospira MLST Zoonosis Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c867c02958e49e5b8335cc17243f1d4
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spelling	oai:doaj.org-article:0c867c02958e49e5b8335cc17243f1d42021-12-01T19:42:30ZEpidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches10.5007/2175-7925.2021.e827690103-16432175-7925https://doaj.org/article/0c867c02958e49e5b8335cc17243f1d42021-12-01T00:00:00Zhttps://periodicos.ufsc.br/index.php/biotemas/article/view/82769https://doaj.org/toc/0103-1643https://doaj.org/toc/2175-7925 Leptospira interrogans is one of the causative agents of human leptospirosis, a zoonotic disease with worldwide distribution. Nowadays, this zoonosis is considered one of the biggest in terms of morbidity and mortality (even considering Dengue, the major arbovirosis affecting humans), having in Brazil 3,800 human cases per year. Currently, difficulties imposed by the absence of a rapid, sensitive diagnostic test that can be used as a routine test for the detection of leptospirosis lead to misdiagnosis and underreported cases. The gold standard diagnostic test for leptospirosis is the microscopic agglutination test (MAT), which presents difficulties in execution and interpretation. Therefore, this review proposes a general view of the epidemiologic situation of the disease in Brazil, in addition to the current contributions in the literature for the development of new diagnostic methods. Amongst them, the gene sequences polymorphism analysis, which presents potential for phylogenetic and populational analysis and genotyping of Leptospira spp. Andressa Penedo de Paiva EstrellaAmanda Silva Hecktheuer Fabienne Antunes FerreiraRicardo Ruiz MazzonUniversidade Federal de Santa CatarinaarticleLeptospiraMLSTZoonosisScienceQBiology (General)QH301-705.5ENESPTBiotemas, Vol 34, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN ES PT
topic	Leptospira MLST Zoonosis Science Q Biology (General) QH301-705.5
spellingShingle	Leptospira MLST Zoonosis Science Q Biology (General) QH301-705.5 Andressa Penedo de Paiva Estrella Amanda Silva Hecktheuer Fabienne Antunes Ferreira Ricardo Ruiz Mazzon Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
description	Leptospira interrogans is one of the causative agents of human leptospirosis, a zoonotic disease with worldwide distribution. Nowadays, this zoonosis is considered one of the biggest in terms of morbidity and mortality (even considering Dengue, the major arbovirosis affecting humans), having in Brazil 3,800 human cases per year. Currently, difficulties imposed by the absence of a rapid, sensitive diagnostic test that can be used as a routine test for the detection of leptospirosis lead to misdiagnosis and underreported cases. The gold standard diagnostic test for leptospirosis is the microscopic agglutination test (MAT), which presents difficulties in execution and interpretation. Therefore, this review proposes a general view of the epidemiologic situation of the disease in Brazil, in addition to the current contributions in the literature for the development of new diagnostic methods. Amongst them, the gene sequences polymorphism analysis, which presents potential for phylogenetic and populational analysis and genotyping of Leptospira spp.
format	article
author	Andressa Penedo de Paiva Estrella Amanda Silva Hecktheuer Fabienne Antunes Ferreira Ricardo Ruiz Mazzon
author_facet	Andressa Penedo de Paiva Estrella Amanda Silva Hecktheuer Fabienne Antunes Ferreira Ricardo Ruiz Mazzon
author_sort	Andressa Penedo de Paiva Estrella
title	Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
title_short	Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
title_full	Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
title_fullStr	Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
title_full_unstemmed	Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches
title_sort	epidemiological situation of human leptospirosis in brazil and challenges in its diagnosis with a focus on molecular approaches
publisher	Universidade Federal de Santa Catarina
publishDate	2021
url	https://doaj.org/article/0c867c02958e49e5b8335cc17243f1d4
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Epidemiological situation of human leptospirosis in Brazil and challenges in its diagnosis with a focus on molecular approaches

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