Androgens, Endometriosis and Pain

The intriguing relationship between androgens, endometriosis and chronic pain continues to unfold. Determining this relationship is of crucial importance to gynecologists managing people with these conditions, as common treatments dramatically alter her hormonal profiles, with both intended and unin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susan F. Evans, M. Louise Hull, Mark R. Hutchinson, Paul E. Rolan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	androgen endometriosis chronic pain aromatase inhibitor hormonal women Reproduction QH471-489 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0c88681d44874561aebead25369500fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c88681d44874561aebead25369500fe
record_format	dspace
spelling	oai:doaj.org-article:0c88681d44874561aebead25369500fe2021-12-03T06:35:41ZAndrogens, Endometriosis and Pain2673-315310.3389/frph.2021.792920https://doaj.org/article/0c88681d44874561aebead25369500fe2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/frph.2021.792920/fullhttps://doaj.org/toc/2673-3153The intriguing relationship between androgens, endometriosis and chronic pain continues to unfold. Determining this relationship is of crucial importance to gynecologists managing people with these conditions, as common treatments dramatically alter her hormonal profiles, with both intended and unintended consequences. Although they may be present in the same individual, there is a recognized disconnect between pain or pain-related symptoms, and the presence or extent of endometriosis lesions. Reduced androgen levels provide a potential mechanism to link the development of endometriosis lesions and the presence of chronic pain. This research paper expands the presentation of our research at the World Endometriosis Congress in 2021, subsequently published in the Journal of Pain Research which demonstrated a strong inverse relationship between androgen levels and days per month of pelvic and period pain. Here we extend and further explore the evidence for a role for androgens in the etiology and management of dysmenorrhea and pelvic pain in women, both with and without endometriosis. We explore the potential for inflammation to induce low androgen levels and consider ways in which clinicians can optimize levels of androgens when treating women with these conditions. This article prompts the question: Is it estrogens that predispose people to a life of pain, or androgens that are protective?Susan F. EvansM. Louise HullM. Louise HullMark R. HutchinsonMark R. HutchinsonPaul E. RolanFrontiers Media S.A.articleandrogenendometriosischronic painaromatase inhibitorhormonalwomenReproductionQH471-489Medicine (General)R5-920ENFrontiers in Reproductive Health, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	androgen endometriosis chronic pain aromatase inhibitor hormonal women Reproduction QH471-489 Medicine (General) R5-920
spellingShingle	androgen endometriosis chronic pain aromatase inhibitor hormonal women Reproduction QH471-489 Medicine (General) R5-920 Susan F. Evans M. Louise Hull M. Louise Hull Mark R. Hutchinson Mark R. Hutchinson Paul E. Rolan Androgens, Endometriosis and Pain
description	The intriguing relationship between androgens, endometriosis and chronic pain continues to unfold. Determining this relationship is of crucial importance to gynecologists managing people with these conditions, as common treatments dramatically alter her hormonal profiles, with both intended and unintended consequences. Although they may be present in the same individual, there is a recognized disconnect between pain or pain-related symptoms, and the presence or extent of endometriosis lesions. Reduced androgen levels provide a potential mechanism to link the development of endometriosis lesions and the presence of chronic pain. This research paper expands the presentation of our research at the World Endometriosis Congress in 2021, subsequently published in the Journal of Pain Research which demonstrated a strong inverse relationship between androgen levels and days per month of pelvic and period pain. Here we extend and further explore the evidence for a role for androgens in the etiology and management of dysmenorrhea and pelvic pain in women, both with and without endometriosis. We explore the potential for inflammation to induce low androgen levels and consider ways in which clinicians can optimize levels of androgens when treating women with these conditions. This article prompts the question: Is it estrogens that predispose people to a life of pain, or androgens that are protective?
format	article
author	Susan F. Evans M. Louise Hull M. Louise Hull Mark R. Hutchinson Mark R. Hutchinson Paul E. Rolan
author_facet	Susan F. Evans M. Louise Hull M. Louise Hull Mark R. Hutchinson Mark R. Hutchinson Paul E. Rolan
author_sort	Susan F. Evans
title	Androgens, Endometriosis and Pain
title_short	Androgens, Endometriosis and Pain
title_full	Androgens, Endometriosis and Pain
title_fullStr	Androgens, Endometriosis and Pain
title_full_unstemmed	Androgens, Endometriosis and Pain
title_sort	androgens, endometriosis and pain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0c88681d44874561aebead25369500fe
work_keys_str_mv	AT susanfevans androgensendometriosisandpain AT mlouisehull androgensendometriosisandpain AT mlouisehull androgensendometriosisandpain AT markrhutchinson androgensendometriosisandpain AT markrhutchinson androgensendometriosisandpain AT paulerolan androgensendometriosisandpain
_version_	1718373853643669504

Androgens, Endometriosis and Pain

Ejemplares similares