Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion

Cells compartmentalize enzymes for enhanced efficiency of their metabolic pathways. Here, the authors describe a self-assembly approach to construct DNA nanocaged enzymes for enhancing catalytic activity and stability, and observe an inversed correlation between the protein size and the activity enh...

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Autores principales:	Zhao Zhao, Jinglin Fu, Soma Dhakal, Alexander Johnson-Buck, Minghui Liu, Ting Zhang, Neal W. Woodbury, Yan Liu, Nils G. Walter, Hao Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c8994d2379840b6bc7c9a797d47c2d7
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spelling	oai:doaj.org-article:0c8994d2379840b6bc7c9a797d47c2d72021-12-02T14:40:15ZNanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion10.1038/ncomms106192041-1723https://doaj.org/article/0c8994d2379840b6bc7c9a797d47c2d72016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10619https://doaj.org/toc/2041-1723Cells compartmentalize enzymes for enhanced efficiency of their metabolic pathways. Here, the authors describe a self-assembly approach to construct DNA nanocaged enzymes for enhancing catalytic activity and stability, and observe an inversed correlation between the protein size and the activity enhancement.Zhao ZhaoJinglin FuSoma DhakalAlexander Johnson-BuckMinghui LiuTing ZhangNeal W. WoodburyYan LiuNils G. WalterHao YanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhao Zhao Jinglin Fu Soma Dhakal Alexander Johnson-Buck Minghui Liu Ting Zhang Neal W. Woodbury Yan Liu Nils G. Walter Hao Yan Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
description	Cells compartmentalize enzymes for enhanced efficiency of their metabolic pathways. Here, the authors describe a self-assembly approach to construct DNA nanocaged enzymes for enhancing catalytic activity and stability, and observe an inversed correlation between the protein size and the activity enhancement.
format	article
author	Zhao Zhao Jinglin Fu Soma Dhakal Alexander Johnson-Buck Minghui Liu Ting Zhang Neal W. Woodbury Yan Liu Nils G. Walter Hao Yan
author_facet	Zhao Zhao Jinglin Fu Soma Dhakal Alexander Johnson-Buck Minghui Liu Ting Zhang Neal W. Woodbury Yan Liu Nils G. Walter Hao Yan
author_sort	Zhao Zhao
title	Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
title_short	Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
title_full	Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
title_fullStr	Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
title_full_unstemmed	Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
title_sort	nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0c8994d2379840b6bc7c9a797d47c2d7
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Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion

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