Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis

Abstract Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and a low level of high-density lipoprotein cholesterol (HDL-C) is also considered to be a predictor for stroke. However, the association between the HDL-C level and asymptomatic ICAS is uncertain. From 2010...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xin Li, Anxin Wang, Jing Wang, Jianwei Wu, Dandan Wang, Xiang Gao, Shouling Wu, Xingquan Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c8c6f7ea7f447e7bd2389fbd435107b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c8c6f7ea7f447e7bd2389fbd435107b
record_format	dspace
spelling	oai:doaj.org-article:0c8c6f7ea7f447e7bd2389fbd435107b2021-12-02T11:41:00ZAssociation between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis10.1038/s41598-017-00596-92045-2322https://doaj.org/article/0c8c6f7ea7f447e7bd2389fbd435107b2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00596-9https://doaj.org/toc/2045-2322Abstract Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and a low level of high-density lipoprotein cholesterol (HDL-C) is also considered to be a predictor for stroke. However, the association between the HDL-C level and asymptomatic ICAS is uncertain. From 2010 to 2011, a random sample of 5,351 participants were enrolled in the Asymptomatic Polyvascular Abnormalities Community (APAC) study. The recruited participants were then separated into 5 roughly uniform-sized factions with varying HDL-C levels. Multivariate logistic regression was implemented to assess the connection of the HDL-C levels and the prevalence of asymptomatic ICAS. The prevalence of asymptomatic ICAS showed no gradual decrease with the increase of HDL-C levels. After adjustment for conventional risk factors, HDL-C levels still showed no significant association with asymptomatic ICAS. The odds ratios (OR) of the prevalence of asymptomatic ICAS between the first group and the other 4 groups were 0.98, 1.00, 0.92, and 0.87 with 95% confidence intervals (CI) being 0.76–1.27, 0.78–1.29, 0.71–1.19, and 0.66–1.13, respectively. The study showed little correlation between HDL-C levels and asymptomatic ICAS. Normal levels of HDL-C are not an independent risk factor for asymptomatic ICAS.Xin LiAnxin WangJing WangJianwei WuDandan WangXiang GaoShouling WuXingquan ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Li Anxin Wang Jing Wang Jianwei Wu Dandan Wang Xiang Gao Shouling Wu Xingquan Zhao Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
description	Abstract Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and a low level of high-density lipoprotein cholesterol (HDL-C) is also considered to be a predictor for stroke. However, the association between the HDL-C level and asymptomatic ICAS is uncertain. From 2010 to 2011, a random sample of 5,351 participants were enrolled in the Asymptomatic Polyvascular Abnormalities Community (APAC) study. The recruited participants were then separated into 5 roughly uniform-sized factions with varying HDL-C levels. Multivariate logistic regression was implemented to assess the connection of the HDL-C levels and the prevalence of asymptomatic ICAS. The prevalence of asymptomatic ICAS showed no gradual decrease with the increase of HDL-C levels. After adjustment for conventional risk factors, HDL-C levels still showed no significant association with asymptomatic ICAS. The odds ratios (OR) of the prevalence of asymptomatic ICAS between the first group and the other 4 groups were 0.98, 1.00, 0.92, and 0.87 with 95% confidence intervals (CI) being 0.76–1.27, 0.78–1.29, 0.71–1.19, and 0.66–1.13, respectively. The study showed little correlation between HDL-C levels and asymptomatic ICAS. Normal levels of HDL-C are not an independent risk factor for asymptomatic ICAS.
format	article
author	Xin Li Anxin Wang Jing Wang Jianwei Wu Dandan Wang Xiang Gao Shouling Wu Xingquan Zhao
author_facet	Xin Li Anxin Wang Jing Wang Jianwei Wu Dandan Wang Xiang Gao Shouling Wu Xingquan Zhao
author_sort	Xin Li
title	Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
title_short	Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
title_full	Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
title_fullStr	Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
title_full_unstemmed	Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis
title_sort	association between high-density-lipoprotein-cholesterol levels and the prevalence of asymptomatic intracranial arterial stenosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c8c6f7ea7f447e7bd2389fbd435107b
work_keys_str_mv	AT xinli associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT anxinwang associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT jingwang associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT jianweiwu associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT dandanwang associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT xianggao associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT shoulingwu associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis AT xingquanzhao associationbetweenhighdensitylipoproteincholesterollevelsandtheprevalenceofasymptomaticintracranialarterialstenosis
_version_	1718395443902152704

Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis

Ejemplares similares