The Role of Diverse Immune Cells in Sarcoidosis

Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical sympt...

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Autores principales: Hui Zhang, Ulrich Costabel, Huaping Dai
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:0c8e3a35c38a4dc8bc70d8a899e687b92021-11-19T07:36:26ZThe Role of Diverse Immune Cells in Sarcoidosis1664-322410.3389/fimmu.2021.788502https://doaj.org/article/0c8e3a35c38a4dc8bc70d8a899e687b92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.788502/fullhttps://doaj.org/toc/1664-3224Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical symptoms, natural history and disease outcomes. Originally described as a Th1-driven disease, sarcoidosis involves a complex interplay among diverse immune cells. This review highlights recent advances in the pathogenesis of sarcoidosis, with emphasis on the role of different immune cells. Accumulative evidence suggests Th17 cells, IFN-γ-producing Th17 cells or Th17.1 cells, and regulatory T (Treg) cells play a critical role. However, their specific actions, whether protective or pathogenic, remain to be clarified. Macrophages are also involved in granuloma formation, and M2 polarization may be predictive of fibrosis. Previously neglected cells including B cells, dendritic cells (DCs), natural killer (NK) cells and natural killer T (NKT) cells were studied more recently for their contribution to sarcoid granuloma formation. Despite these advances, the pathogenesis remains incompletely understood, indicating an urgent need for further research to reveal the distinct immunological events in this process, with hope to open up new therapeutic avenues and if possible, to develop preventive measures.Hui ZhangUlrich CostabelHuaping DaiHuaping DaiHuaping DaiHuaping DaiFrontiers Media S.A.articlesarcoidosisTh17 cellsregulatory T cellsmacrophagesB cellsdendritic cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic sarcoidosis
Th17 cells
regulatory T cells
macrophages
B cells
dendritic cells
Immunologic diseases. Allergy
RC581-607
spellingShingle sarcoidosis
Th17 cells
regulatory T cells
macrophages
B cells
dendritic cells
Immunologic diseases. Allergy
RC581-607
Hui Zhang
Ulrich Costabel
Huaping Dai
Huaping Dai
Huaping Dai
Huaping Dai
The Role of Diverse Immune Cells in Sarcoidosis
description Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical symptoms, natural history and disease outcomes. Originally described as a Th1-driven disease, sarcoidosis involves a complex interplay among diverse immune cells. This review highlights recent advances in the pathogenesis of sarcoidosis, with emphasis on the role of different immune cells. Accumulative evidence suggests Th17 cells, IFN-γ-producing Th17 cells or Th17.1 cells, and regulatory T (Treg) cells play a critical role. However, their specific actions, whether protective or pathogenic, remain to be clarified. Macrophages are also involved in granuloma formation, and M2 polarization may be predictive of fibrosis. Previously neglected cells including B cells, dendritic cells (DCs), natural killer (NK) cells and natural killer T (NKT) cells were studied more recently for their contribution to sarcoid granuloma formation. Despite these advances, the pathogenesis remains incompletely understood, indicating an urgent need for further research to reveal the distinct immunological events in this process, with hope to open up new therapeutic avenues and if possible, to develop preventive measures.
format article
author Hui Zhang
Ulrich Costabel
Huaping Dai
Huaping Dai
Huaping Dai
Huaping Dai
author_facet Hui Zhang
Ulrich Costabel
Huaping Dai
Huaping Dai
Huaping Dai
Huaping Dai
author_sort Hui Zhang
title The Role of Diverse Immune Cells in Sarcoidosis
title_short The Role of Diverse Immune Cells in Sarcoidosis
title_full The Role of Diverse Immune Cells in Sarcoidosis
title_fullStr The Role of Diverse Immune Cells in Sarcoidosis
title_full_unstemmed The Role of Diverse Immune Cells in Sarcoidosis
title_sort role of diverse immune cells in sarcoidosis
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/0c8e3a35c38a4dc8bc70d8a899e687b9
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