The Role of Diverse Immune Cells in Sarcoidosis
Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical sympt...
Guardado en:
Autores principales: | , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0c8e3a35c38a4dc8bc70d8a899e687b9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:0c8e3a35c38a4dc8bc70d8a899e687b9 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:0c8e3a35c38a4dc8bc70d8a899e687b92021-11-19T07:36:26ZThe Role of Diverse Immune Cells in Sarcoidosis1664-322410.3389/fimmu.2021.788502https://doaj.org/article/0c8e3a35c38a4dc8bc70d8a899e687b92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.788502/fullhttps://doaj.org/toc/1664-3224Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical symptoms, natural history and disease outcomes. Originally described as a Th1-driven disease, sarcoidosis involves a complex interplay among diverse immune cells. This review highlights recent advances in the pathogenesis of sarcoidosis, with emphasis on the role of different immune cells. Accumulative evidence suggests Th17 cells, IFN-γ-producing Th17 cells or Th17.1 cells, and regulatory T (Treg) cells play a critical role. However, their specific actions, whether protective or pathogenic, remain to be clarified. Macrophages are also involved in granuloma formation, and M2 polarization may be predictive of fibrosis. Previously neglected cells including B cells, dendritic cells (DCs), natural killer (NK) cells and natural killer T (NKT) cells were studied more recently for their contribution to sarcoid granuloma formation. Despite these advances, the pathogenesis remains incompletely understood, indicating an urgent need for further research to reveal the distinct immunological events in this process, with hope to open up new therapeutic avenues and if possible, to develop preventive measures.Hui ZhangUlrich CostabelHuaping DaiHuaping DaiHuaping DaiHuaping DaiFrontiers Media S.A.articlesarcoidosisTh17 cellsregulatory T cellsmacrophagesB cellsdendritic cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
sarcoidosis Th17 cells regulatory T cells macrophages B cells dendritic cells Immunologic diseases. Allergy RC581-607 |
spellingShingle |
sarcoidosis Th17 cells regulatory T cells macrophages B cells dendritic cells Immunologic diseases. Allergy RC581-607 Hui Zhang Ulrich Costabel Huaping Dai Huaping Dai Huaping Dai Huaping Dai The Role of Diverse Immune Cells in Sarcoidosis |
description |
Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue infiltration with macrophages and lymphocytes and associated non-caseating granuloma formation. The disease primarily affects the lungs. Patients suffering from sarcoidosis show a wide range of clinical symptoms, natural history and disease outcomes. Originally described as a Th1-driven disease, sarcoidosis involves a complex interplay among diverse immune cells. This review highlights recent advances in the pathogenesis of sarcoidosis, with emphasis on the role of different immune cells. Accumulative evidence suggests Th17 cells, IFN-γ-producing Th17 cells or Th17.1 cells, and regulatory T (Treg) cells play a critical role. However, their specific actions, whether protective or pathogenic, remain to be clarified. Macrophages are also involved in granuloma formation, and M2 polarization may be predictive of fibrosis. Previously neglected cells including B cells, dendritic cells (DCs), natural killer (NK) cells and natural killer T (NKT) cells were studied more recently for their contribution to sarcoid granuloma formation. Despite these advances, the pathogenesis remains incompletely understood, indicating an urgent need for further research to reveal the distinct immunological events in this process, with hope to open up new therapeutic avenues and if possible, to develop preventive measures. |
format |
article |
author |
Hui Zhang Ulrich Costabel Huaping Dai Huaping Dai Huaping Dai Huaping Dai |
author_facet |
Hui Zhang Ulrich Costabel Huaping Dai Huaping Dai Huaping Dai Huaping Dai |
author_sort |
Hui Zhang |
title |
The Role of Diverse Immune Cells in Sarcoidosis |
title_short |
The Role of Diverse Immune Cells in Sarcoidosis |
title_full |
The Role of Diverse Immune Cells in Sarcoidosis |
title_fullStr |
The Role of Diverse Immune Cells in Sarcoidosis |
title_full_unstemmed |
The Role of Diverse Immune Cells in Sarcoidosis |
title_sort |
role of diverse immune cells in sarcoidosis |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/0c8e3a35c38a4dc8bc70d8a899e687b9 |
work_keys_str_mv |
AT huizhang theroleofdiverseimmunecellsinsarcoidosis AT ulrichcostabel theroleofdiverseimmunecellsinsarcoidosis AT huapingdai theroleofdiverseimmunecellsinsarcoidosis AT huapingdai theroleofdiverseimmunecellsinsarcoidosis AT huapingdai theroleofdiverseimmunecellsinsarcoidosis AT huapingdai theroleofdiverseimmunecellsinsarcoidosis AT huizhang roleofdiverseimmunecellsinsarcoidosis AT ulrichcostabel roleofdiverseimmunecellsinsarcoidosis AT huapingdai roleofdiverseimmunecellsinsarcoidosis AT huapingdai roleofdiverseimmunecellsinsarcoidosis AT huapingdai roleofdiverseimmunecellsinsarcoidosis AT huapingdai roleofdiverseimmunecellsinsarcoidosis |
_version_ |
1718420237430292480 |