Harnessing CD8+CD28− Regulatory T Cells as a Tool to Treat Autoimmune Disease

T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4+ Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In t...

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Autores principales:	Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CD8 Treg autoimmunity immunoregulation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c8f856cc5e947cdb4c5cf8bd03897b0
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spelling	oai:doaj.org-article:0c8f856cc5e947cdb4c5cf8bd03897b02021-11-25T17:09:55ZHarnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease10.3390/cells101129732073-4409https://doaj.org/article/0c8f856cc5e947cdb4c5cf8bd03897b02021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2973https://doaj.org/toc/2073-4409T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4<sup>+</sup> Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8<sup>+</sup> Tregs and their role in murine and human disease indications. A subset of CD8<sup>+</sup> Tregs that lack the surface expression of CD28 (CD8<sup>+</sup>CD28<sup>−</sup> Treg) has proved efficacious in preclinical models. CD8<sup>+</sup>CD28<sup>−</sup> Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8<sup>+</sup> Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions.Sabrina CeerazCharlotte R. ThompsonRichard BeatsonErnest H. ChoyMDPI AGarticleCD8TregautoimmunityimmunoregulationBiology (General)QH301-705.5ENCells, Vol 10, Iss 2973, p 2973 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD8 Treg autoimmunity immunoregulation Biology (General) QH301-705.5
spellingShingle	CD8 Treg autoimmunity immunoregulation Biology (General) QH301-705.5 Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
description	T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4<sup>+</sup> Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8<sup>+</sup> Tregs and their role in murine and human disease indications. A subset of CD8<sup>+</sup> Tregs that lack the surface expression of CD28 (CD8<sup>+</sup>CD28<sup>−</sup> Treg) has proved efficacious in preclinical models. CD8<sup>+</sup>CD28<sup>−</sup> Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8<sup>+</sup> Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions.
format	article
author	Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy
author_facet	Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy
author_sort	Sabrina Ceeraz
title	Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
title_short	Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
title_full	Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
title_fullStr	Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
title_full_unstemmed	Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
title_sort	harnessing cd8<sup>+</sup>cd28<sup>−</sup> regulatory t cells as a tool to treat autoimmune disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c8f856cc5e947cdb4c5cf8bd03897b0
work_keys_str_mv	AT sabrinaceeraz harnessingcd8supsupcd28supsupregulatorytcellsasatooltotreatautoimmunedisease AT charlotterthompson harnessingcd8supsupcd28supsupregulatorytcellsasatooltotreatautoimmunedisease AT richardbeatson harnessingcd8supsupcd28supsupregulatorytcellsasatooltotreatautoimmunedisease AT ernesthchoy harnessingcd8supsupcd28supsupregulatorytcellsasatooltotreatautoimmunedisease
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Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease

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