Directional translocation resistance of Zika xrRNA
Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfoldin...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/0c8f977208a6439691205b8011ea62e7 |
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| Sumario: | Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfolding; pulling the $${5}^{\prime}$$ 5′ end, as done by exonucleases, triggers molecular tightening. |
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