Directional translocation resistance of Zika xrRNA

Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfoldin...

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Autores principales:	Antonio Suma, Lucia Coronel, Giovanni Bussi, Cristian Micheletti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c8f977208a6439691205b8011ea62e7
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spelling	oai:doaj.org-article:0c8f977208a6439691205b8011ea62e72021-12-02T18:47:02ZDirectional translocation resistance of Zika xrRNA10.1038/s41467-020-17508-72041-1723https://doaj.org/article/0c8f977208a6439691205b8011ea62e72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17508-7https://doaj.org/toc/2041-1723Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfolding; pulling the $${5}^{\prime}$$ 5′ end, as done by exonucleases, triggers molecular tightening.Antonio SumaLucia CoronelGiovanni BussiCristian MichelettiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonio Suma Lucia Coronel Giovanni Bussi Cristian Micheletti Directional translocation resistance of Zika xrRNA
description	Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfolding; pulling the $${5}^{\prime}$$ 5′ end, as done by exonucleases, triggers molecular tightening.
format	article
author	Antonio Suma Lucia Coronel Giovanni Bussi Cristian Micheletti
author_facet	Antonio Suma Lucia Coronel Giovanni Bussi Cristian Micheletti
author_sort	Antonio Suma
title	Directional translocation resistance of Zika xrRNA
title_short	Directional translocation resistance of Zika xrRNA
title_full	Directional translocation resistance of Zika xrRNA
title_fullStr	Directional translocation resistance of Zika xrRNA
title_full_unstemmed	Directional translocation resistance of Zika xrRNA
title_sort	directional translocation resistance of zika xrrna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c8f977208a6439691205b8011ea62e7
work_keys_str_mv	AT antoniosuma directionaltranslocationresistanceofzikaxrrna AT luciacoronel directionaltranslocationresistanceofzikaxrrna AT giovannibussi directionaltranslocationresistanceofzikaxrrna AT cristianmicheletti directionaltranslocationresistanceofzikaxrrna
_version_	1718377662926290944

Directional translocation resistance of Zika xrRNA

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