Directional translocation resistance of Zika xrRNA

Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as done by replicases, causes progressive unfoldin...

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Autores principales: Antonio Suma, Lucia Coronel, Giovanni Bussi, Cristian Micheletti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0c8f977208a6439691205b8011ea62e7
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