Anti-Osteoporosis Effects of the Eleutherococcus senticosus, Achyranthes japonica, and Atractylodes japonica Mixed Extract Fermented with Nuruk

Vigeo is a mixture of fermented extracts of Eleutherococcus senticosus Maxim (ESM), Achyranthes japonica (Miq.) Nakai (AJN), and Atractylodes japonica Koidzumi (AJK) manufactured using the traditional Korean nuruk fermentation method. Although...

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Autores principales:	So Young Eun, Yoon-Hee Cheon, Gyeong Do Park, Chong Hyuk Chung, Chang Hoon Lee, Ju-Young Kim, Myeung Su Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Vigeo nuruk fermentation osteoclasts bone resorption osteoporosis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0c90b92aa7024a71b9d360715e3b3524
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spelling	oai:doaj.org-article:0c90b92aa7024a71b9d360715e3b35242021-11-25T18:35:08ZAnti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk10.3390/nu131139042072-6643https://doaj.org/article/0c90b92aa7024a71b9d360715e3b35242021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3904https://doaj.org/toc/2072-6643Vigeo is a mixture of fermented extracts of <i>Eleutherococcus senticosus</i> Maxim (ESM), <i>Achyranthes japonica</i> (Miq.) Nakai (AJN), and <i>Atractylodes japonica</i> Koidzumi (AJK) manufactured using the traditional Korean nuruk fermentation method. Although the bioactive effects of ESM, AJN, and AJK have already been reported, the pharmacological effects of Vigeo have not been proven. Therefore, in this study, we investigated whether Vigeo had inhivitory effects on lipopolysaccharide (LPS)-induced inflammatory bone loss in vivo and receptor activator of nuclear factor-B ligand (RANKL)-induced osteoclastogenesis and the related mechanism in vitro. Vigeo administration conferred effective protection against bone loss induced by excessive inflammatory response and activity of osteoclasts in LPS-induced inflammatory osteoporosis mouse model. In addition, Vigeo significantly suppressed the formation of tartrate-resistant acid phosphatase-positive osteoclasts induced by RANKL and inhibited F-actin formation and bone resorbing activity without any cytotoxicity. Moreover, Vigeo significantly inhibited RANKL-induced phosphorylation of p38, ERK, JNK, IκB, and AKT and degradation of IkB. Additionally, Vigeo strongly inhibited the mRNA and protein expression of c-FOS and NFATc1 and subsequently attenuated the expression of osteoclast specific marker genes induced by RANKL. We demonstrated for the first time the anti-osteoporosis effect of Vigeo, suggesting that it could be a potential therapeutic candidate for the treatment of osteoclast-mediated inflammatory bone diseases.So Young EunYoon-Hee CheonGyeong Do ParkChong Hyuk ChungChang Hoon LeeJu-Young KimMyeung Su LeeMDPI AGarticleVigeonuruk fermentationosteoclastsbone resorptionosteoporosisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3904, p 3904 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vigeo nuruk fermentation osteoclasts bone resorption osteoporosis Nutrition. Foods and food supply TX341-641
spellingShingle	Vigeo nuruk fermentation osteoclasts bone resorption osteoporosis Nutrition. Foods and food supply TX341-641 So Young Eun Yoon-Hee Cheon Gyeong Do Park Chong Hyuk Chung Chang Hoon Lee Ju-Young Kim Myeung Su Lee Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
description	Vigeo is a mixture of fermented extracts of <i>Eleutherococcus senticosus</i> Maxim (ESM), <i>Achyranthes japonica</i> (Miq.) Nakai (AJN), and <i>Atractylodes japonica</i> Koidzumi (AJK) manufactured using the traditional Korean nuruk fermentation method. Although the bioactive effects of ESM, AJN, and AJK have already been reported, the pharmacological effects of Vigeo have not been proven. Therefore, in this study, we investigated whether Vigeo had inhivitory effects on lipopolysaccharide (LPS)-induced inflammatory bone loss in vivo and receptor activator of nuclear factor-B ligand (RANKL)-induced osteoclastogenesis and the related mechanism in vitro. Vigeo administration conferred effective protection against bone loss induced by excessive inflammatory response and activity of osteoclasts in LPS-induced inflammatory osteoporosis mouse model. In addition, Vigeo significantly suppressed the formation of tartrate-resistant acid phosphatase-positive osteoclasts induced by RANKL and inhibited F-actin formation and bone resorbing activity without any cytotoxicity. Moreover, Vigeo significantly inhibited RANKL-induced phosphorylation of p38, ERK, JNK, IκB, and AKT and degradation of IkB. Additionally, Vigeo strongly inhibited the mRNA and protein expression of c-FOS and NFATc1 and subsequently attenuated the expression of osteoclast specific marker genes induced by RANKL. We demonstrated for the first time the anti-osteoporosis effect of Vigeo, suggesting that it could be a potential therapeutic candidate for the treatment of osteoclast-mediated inflammatory bone diseases.
format	article
author	So Young Eun Yoon-Hee Cheon Gyeong Do Park Chong Hyuk Chung Chang Hoon Lee Ju-Young Kim Myeung Su Lee
author_facet	So Young Eun Yoon-Hee Cheon Gyeong Do Park Chong Hyuk Chung Chang Hoon Lee Ju-Young Kim Myeung Su Lee
author_sort	So Young Eun
title	Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
title_short	Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
title_full	Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
title_fullStr	Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
title_full_unstemmed	Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk
title_sort	anti-osteoporosis effects of the <i>eleutherococcus senticosus</i>, <i>achyranthes japonica</i>, and <i>atractylodes japonica</i> mixed extract fermented with nuruk
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c90b92aa7024a71b9d360715e3b3524
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Anti-Osteoporosis Effects of the <i>Eleutherococcus senticosus</i>, <i>Achyranthes japonica</i>, and <i>Atractylodes japonica</i> Mixed Extract Fermented with Nuruk

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