Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review

Paul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monocl...

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Autores principales:	Elsbernd PM, Carter JL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	monoclonal antibodies multiple sclerosis relapsing progressive review Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0c91e8bc3c8248e58ce948176146391f
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spelling	oai:doaj.org-article:0c91e8bc3c8248e58ce948176146391f2021-12-02T14:34:18ZUsing Monoclonal Antibody Therapies for Multiple Sclerosis: A Review1177-5491https://doaj.org/article/0c91e8bc3c8248e58ce948176146391f2021-06-01T00:00:00Zhttps://www.dovepress.com/using-monoclonal-antibody-therapies-for-multiple-sclerosis-a-review-peer-reviewed-fulltext-article-BTThttps://doaj.org/toc/1177-5491Paul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monoclonal antibody therapies have secured an important role in the therapeutic landscape for the treatment of both relapsing and progressive forms of multiple sclerosis due to their potent efficacy, convenient dosing schedules, and well-defined side effect profiles. Each therapy has unique risks and benefits associated with its specific mechanism of action which ultimately guides clinical decision-making for individual patients. This review will summarize the mechanisms of action, evidence leading to their approval, and clinically relevant considerations for each of the current monoclonal antibody therapies approved for the treatment of multiple sclerosis.Keywords: monoclonal antibodies, multiple sclerosis, relapsing, progressive, reviewElsbernd PMCarter JLDove Medical Pressarticlemonoclonal antibodiesmultiple sclerosisrelapsingprogressivereviewMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 255-263 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	monoclonal antibodies multiple sclerosis relapsing progressive review Medicine (General) R5-920
spellingShingle	monoclonal antibodies multiple sclerosis relapsing progressive review Medicine (General) R5-920 Elsbernd PM Carter JL Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
description	Paul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monoclonal antibody therapies have secured an important role in the therapeutic landscape for the treatment of both relapsing and progressive forms of multiple sclerosis due to their potent efficacy, convenient dosing schedules, and well-defined side effect profiles. Each therapy has unique risks and benefits associated with its specific mechanism of action which ultimately guides clinical decision-making for individual patients. This review will summarize the mechanisms of action, evidence leading to their approval, and clinically relevant considerations for each of the current monoclonal antibody therapies approved for the treatment of multiple sclerosis.Keywords: monoclonal antibodies, multiple sclerosis, relapsing, progressive, review
format	article
author	Elsbernd PM Carter JL
author_facet	Elsbernd PM Carter JL
author_sort	Elsbernd PM
title	Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
title_short	Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
title_full	Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
title_fullStr	Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
title_full_unstemmed	Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
title_sort	using monoclonal antibody therapies for multiple sclerosis: a review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0c91e8bc3c8248e58ce948176146391f
work_keys_str_mv	AT elsberndpm usingmonoclonalantibodytherapiesformultiplesclerosisareview AT carterjl usingmonoclonalantibodytherapiesformultiplesclerosisareview
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Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review

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