Spleen contributes to restraint stress induced changes in blood leukocytes distribution

Abstract Psychological stress has great impacts on the immune system, particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied, however, it remains unclear how chronic stress affects leukocytes distribution in peripheral circula...

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Autores principales:	Wei Jiang, Yu Li, Jin Sun, Liang Li, Jiang-wei Li, Chen Zhang, Chen Huang, Jun Yang, Guang-yao Kong, Zong-fang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c9482f1d85e4961a0d2265880c18d9c
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spelling	oai:doaj.org-article:0c9482f1d85e4961a0d2265880c18d9c2021-12-02T15:05:48ZSpleen contributes to restraint stress induced changes in blood leukocytes distribution10.1038/s41598-017-06956-92045-2322https://doaj.org/article/0c9482f1d85e4961a0d2265880c18d9c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06956-9https://doaj.org/toc/2045-2322Abstract Psychological stress has great impacts on the immune system, particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied, however, it remains unclear how chronic stress affects leukocytes distribution in peripheral circulation. Furthermore, there is no report about the role of spleen in the blood leukocytes distribution induced by stress. Here we show that spleen contributes to the alteration of restraint stress induced blood leukocytes distribution. Our data confirmed that restraint stress induced anxiety-like behavior in mice. Furthermore, we found that restraint stress decreased the CD4/CD8 ratio and elevated the percentages of natural killer cells, monocytes and polymorphonuclear myeloid-derived suppressor cell. We demonstrated that activation of hypothalamic-pituitary-adrenal axis (HPA) and sympathetic nervous system (SNS) contributes to restraint stress induced alteration of blood leukocyte distribution. Interestingly, we found that splenectomy could reverse the change of CD4/CD8 ratio induced by restraint stress. Together, our findings suggest that activation of HPA axis and SNS was responsible for the blood leukocyte subsets changes induced by restraint stress. Spleen, at least in part, contributed to the alteration in peripheral circulation induced by restraint stress.Wei JiangYu LiJin SunLiang LiJiang-wei LiChen ZhangChen HuangJun YangGuang-yao KongZong-fang LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Jiang Yu Li Jin Sun Liang Li Jiang-wei Li Chen Zhang Chen Huang Jun Yang Guang-yao Kong Zong-fang Li Spleen contributes to restraint stress induced changes in blood leukocytes distribution
description	Abstract Psychological stress has great impacts on the immune system, particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied, however, it remains unclear how chronic stress affects leukocytes distribution in peripheral circulation. Furthermore, there is no report about the role of spleen in the blood leukocytes distribution induced by stress. Here we show that spleen contributes to the alteration of restraint stress induced blood leukocytes distribution. Our data confirmed that restraint stress induced anxiety-like behavior in mice. Furthermore, we found that restraint stress decreased the CD4/CD8 ratio and elevated the percentages of natural killer cells, monocytes and polymorphonuclear myeloid-derived suppressor cell. We demonstrated that activation of hypothalamic-pituitary-adrenal axis (HPA) and sympathetic nervous system (SNS) contributes to restraint stress induced alteration of blood leukocyte distribution. Interestingly, we found that splenectomy could reverse the change of CD4/CD8 ratio induced by restraint stress. Together, our findings suggest that activation of HPA axis and SNS was responsible for the blood leukocyte subsets changes induced by restraint stress. Spleen, at least in part, contributed to the alteration in peripheral circulation induced by restraint stress.
format	article
author	Wei Jiang Yu Li Jin Sun Liang Li Jiang-wei Li Chen Zhang Chen Huang Jun Yang Guang-yao Kong Zong-fang Li
author_facet	Wei Jiang Yu Li Jin Sun Liang Li Jiang-wei Li Chen Zhang Chen Huang Jun Yang Guang-yao Kong Zong-fang Li
author_sort	Wei Jiang
title	Spleen contributes to restraint stress induced changes in blood leukocytes distribution
title_short	Spleen contributes to restraint stress induced changes in blood leukocytes distribution
title_full	Spleen contributes to restraint stress induced changes in blood leukocytes distribution
title_fullStr	Spleen contributes to restraint stress induced changes in blood leukocytes distribution
title_full_unstemmed	Spleen contributes to restraint stress induced changes in blood leukocytes distribution
title_sort	spleen contributes to restraint stress induced changes in blood leukocytes distribution
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c9482f1d85e4961a0d2265880c18d9c
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_version_	1718388687684763648

Spleen contributes to restraint stress induced changes in blood leukocytes distribution

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