Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNP...

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Autores principales:	Angela B. Javurek, Dhananjay Suresh, William G. Spollen, Marcia L. Hart, Sarah A. Hansen, Mark R. Ellersieck, Nathan J. Bivens, Scott A. Givan, Anandhi Upendran, Raghuraman Kannan, Cheryl S. Rosenfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c97909e60b44dc2a6a5ac86c7478e9c
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spelling	oai:doaj.org-article:0c97909e60b44dc2a6a5ac86c7478e9c2021-12-02T12:30:54ZGut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles10.1038/s41598-017-02880-02045-2322https://doaj.org/article/0c97909e60b44dc2a6a5ac86c7478e9c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02880-0https://doaj.org/toc/2045-2322Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNPs result in gut dysbiosis and other changes within the host. We sought to examine whether exposure of Sprague-Dawley male rats for two weeks to different shapes of AgNPs, cube (AgNC) and sphere (AgNS) affects gut microbiota, select behaviors, and induces histopathological changes in the gastrointestinal system and brain. In the elevated plus maze (EPM), AgNS-exposed rats showed greater number of entries into closed arms and center compared to controls and those exposed to AgNC. AgNS and AgNC treated groups had select reductions in gut microbiota relative to controls. Clostridium spp., Bacteroides uniformis, Christensenellaceae, and Coprococcus eutactus were decreased in AgNC exposed group, whereas, Oscillospira spp., Dehalobacterium spp., Peptococcaeceae, Corynebacterium spp., Aggregatibacter pneumotropica were reduced in AgNS exposed group. Bacterial reductions correlated with select behavioral changes measured in the EPM. No significant histopathological changes were evident in the gastrointestinal system or brain. Findings suggest short-term exposure to AgNS or AgNC can lead to behavioral and gut microbiome changes.Angela B. JavurekDhananjay SureshWilliam G. SpollenMarcia L. HartSarah A. HansenMark R. EllersieckNathan J. BivensScott A. GivanAnandhi UpendranRaghuraman KannanCheryl S. RosenfeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angela B. Javurek Dhananjay Suresh William G. Spollen Marcia L. Hart Sarah A. Hansen Mark R. Ellersieck Nathan J. Bivens Scott A. Givan Anandhi Upendran Raghuraman Kannan Cheryl S. Rosenfeld Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
description	Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNPs result in gut dysbiosis and other changes within the host. We sought to examine whether exposure of Sprague-Dawley male rats for two weeks to different shapes of AgNPs, cube (AgNC) and sphere (AgNS) affects gut microbiota, select behaviors, and induces histopathological changes in the gastrointestinal system and brain. In the elevated plus maze (EPM), AgNS-exposed rats showed greater number of entries into closed arms and center compared to controls and those exposed to AgNC. AgNS and AgNC treated groups had select reductions in gut microbiota relative to controls. Clostridium spp., Bacteroides uniformis, Christensenellaceae, and Coprococcus eutactus were decreased in AgNC exposed group, whereas, Oscillospira spp., Dehalobacterium spp., Peptococcaeceae, Corynebacterium spp., Aggregatibacter pneumotropica were reduced in AgNS exposed group. Bacterial reductions correlated with select behavioral changes measured in the EPM. No significant histopathological changes were evident in the gastrointestinal system or brain. Findings suggest short-term exposure to AgNS or AgNC can lead to behavioral and gut microbiome changes.
format	article
author	Angela B. Javurek Dhananjay Suresh William G. Spollen Marcia L. Hart Sarah A. Hansen Mark R. Ellersieck Nathan J. Bivens Scott A. Givan Anandhi Upendran Raghuraman Kannan Cheryl S. Rosenfeld
author_facet	Angela B. Javurek Dhananjay Suresh William G. Spollen Marcia L. Hart Sarah A. Hansen Mark R. Ellersieck Nathan J. Bivens Scott A. Givan Anandhi Upendran Raghuraman Kannan Cheryl S. Rosenfeld
author_sort	Angela B. Javurek
title	Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
title_short	Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
title_full	Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
title_fullStr	Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
title_full_unstemmed	Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
title_sort	gut dysbiosis and neurobehavioral alterations in rats exposed to silver nanoparticles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c97909e60b44dc2a6a5ac86c7478e9c
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Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

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