miR-9a modulates maintenance and ageing of Drosophila germline stem cells by limiting N-cadherin expression

In the Drosophila testis, ageing leads to loss of germline stem cells. Here, the authors show that, during ageing in Drosophila, miR-9a is upregulated in male germline stem cells and regulates their proliferation by targeting N-cadherin.

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Autores principales: Yehonatan Epstein, Noam Perry, Marina Volin, Maayan Zohar-Fux, Rachel Braun, Lilach Porat-Kuperstein, Hila Toledano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0c9869733bd54454ab88c0c74b86801a
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Sumario:In the Drosophila testis, ageing leads to loss of germline stem cells. Here, the authors show that, during ageing in Drosophila, miR-9a is upregulated in male germline stem cells and regulates their proliferation by targeting N-cadherin.