Metabolism in Retinopathy of Prematurity

Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth. Both neuronal maturation and retinal vascularization are impaired, leading to the compensatory but uncontrolled retina...

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Autores principales:	Yohei Tomita, Ayumi Usui-Ouchi, Anders K. Nilsson, Jay Yang, Minji Ko, Ann Hellström, Zhongjie Fu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinopathy of prematurity neovascularization retinal metabolism hyperglycemia dyslipidemia oxygen-induced retinopathy Science Q
Acceso en línea:	https://doaj.org/article/0c9b09a8af7d4b9ca4cbae7f39f64509
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spelling	oai:doaj.org-article:0c9b09a8af7d4b9ca4cbae7f39f645092021-11-25T18:10:26ZMetabolism in Retinopathy of Prematurity10.3390/life111111192075-1729https://doaj.org/article/0c9b09a8af7d4b9ca4cbae7f39f645092021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1119https://doaj.org/toc/2075-1729Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth. Both neuronal maturation and retinal vascularization are impaired, leading to the compensatory but uncontrolled retinal neovessel growth. Current therapeutic interventions target the hypoxia-induced neovessels but negatively impact retinal neurons and normal vessels. Emerging evidence suggests that metabolic disturbance is a significant and underexplored risk factor in the disease pathogenesis. Hyperglycemia and dyslipidemia correlate with the retinal neurovascular dysfunction in infants born prematurely. Nutritional and hormonal supplementation relieve metabolic stress and improve retinal maturation. Here we focus on the mechanisms through which metabolism is involved in preterm-birth-related retinal disorder from clinical and experimental investigations. We will review and discuss potential therapeutic targets through the restoration of metabolic responses to prevent disease development and progression.Yohei TomitaAyumi Usui-OuchiAnders K. NilssonJay YangMinji KoAnn HellströmZhongjie FuMDPI AGarticleretinopathy of prematurityneovascularizationretinal metabolismhyperglycemiadyslipidemiaoxygen-induced retinopathyScienceQENLife, Vol 11, Iss 1119, p 1119 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinopathy of prematurity neovascularization retinal metabolism hyperglycemia dyslipidemia oxygen-induced retinopathy Science Q
spellingShingle	retinopathy of prematurity neovascularization retinal metabolism hyperglycemia dyslipidemia oxygen-induced retinopathy Science Q Yohei Tomita Ayumi Usui-Ouchi Anders K. Nilsson Jay Yang Minji Ko Ann Hellström Zhongjie Fu Metabolism in Retinopathy of Prematurity
description	Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth. Both neuronal maturation and retinal vascularization are impaired, leading to the compensatory but uncontrolled retinal neovessel growth. Current therapeutic interventions target the hypoxia-induced neovessels but negatively impact retinal neurons and normal vessels. Emerging evidence suggests that metabolic disturbance is a significant and underexplored risk factor in the disease pathogenesis. Hyperglycemia and dyslipidemia correlate with the retinal neurovascular dysfunction in infants born prematurely. Nutritional and hormonal supplementation relieve metabolic stress and improve retinal maturation. Here we focus on the mechanisms through which metabolism is involved in preterm-birth-related retinal disorder from clinical and experimental investigations. We will review and discuss potential therapeutic targets through the restoration of metabolic responses to prevent disease development and progression.
format	article
author	Yohei Tomita Ayumi Usui-Ouchi Anders K. Nilsson Jay Yang Minji Ko Ann Hellström Zhongjie Fu
author_facet	Yohei Tomita Ayumi Usui-Ouchi Anders K. Nilsson Jay Yang Minji Ko Ann Hellström Zhongjie Fu
author_sort	Yohei Tomita
title	Metabolism in Retinopathy of Prematurity
title_short	Metabolism in Retinopathy of Prematurity
title_full	Metabolism in Retinopathy of Prematurity
title_fullStr	Metabolism in Retinopathy of Prematurity
title_full_unstemmed	Metabolism in Retinopathy of Prematurity
title_sort	metabolism in retinopathy of prematurity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c9b09a8af7d4b9ca4cbae7f39f64509
work_keys_str_mv	AT yoheitomita metabolisminretinopathyofprematurity AT ayumiusuiouchi metabolisminretinopathyofprematurity AT andersknilsson metabolisminretinopathyofprematurity AT jayyang metabolisminretinopathyofprematurity AT minjiko metabolisminretinopathyofprematurity AT annhellstrom metabolisminretinopathyofprematurity AT zhongjiefu metabolisminretinopathyofprematurity
_version_	1718411481808109568

Metabolism in Retinopathy of Prematurity

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