RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl t...

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Autores principales:	Heehwa G. Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A. An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N. Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T. Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc7
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spelling	oai:doaj.org-article:0c9bbbde0d4b4ce0a1014b73350edcc72021-12-02T17:01:24ZRNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans10.1038/ncomms147492041-1723https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc72017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14749https://doaj.org/toc/2041-1723The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.Heehwa G. SonMihwa SeoSeokjin HamWooseon HwangDongyeop LeeSeon Woo A. AnMurat ArtanKeunhee SeoRachel KaletskyRachel N. AreyYoungjae RyuChang Man HaYoon Ki KimColeen T. MurphyTae-Young RohHong Gil NamSeung-Jae V. LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heehwa G. Son Mihwa Seo Seokjin Ham Wooseon Hwang Dongyeop Lee Seon Woo A. An Murat Artan Keunhee Seo Rachel Kaletsky Rachel N. Arey Youngjae Ryu Chang Man Ha Yoon Ki Kim Coleen T. Murphy Tae-Young Roh Hong Gil Nam Seung-Jae V. Lee RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
description	The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.
format	article
author	Heehwa G. Son Mihwa Seo Seokjin Ham Wooseon Hwang Dongyeop Lee Seon Woo A. An Murat Artan Keunhee Seo Rachel Kaletsky Rachel N. Arey Youngjae Ryu Chang Man Ha Yoon Ki Kim Coleen T. Murphy Tae-Young Roh Hong Gil Nam Seung-Jae V. Lee
author_facet	Heehwa G. Son Mihwa Seo Seokjin Ham Wooseon Hwang Dongyeop Lee Seon Woo A. An Murat Artan Keunhee Seo Rachel Kaletsky Rachel N. Arey Youngjae Ryu Chang Man Ha Yoon Ki Kim Coleen T. Murphy Tae-Young Roh Hong Gil Nam Seung-Jae V. Lee
author_sort	Heehwa G. Son
title	RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
title_short	RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
title_full	RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
title_fullStr	RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
title_full_unstemmed	RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
title_sort	rna surveillance via nonsense-mediated mrna decay is crucial for longevity in daf-2/insulin/igf-1 mutant c. elegans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc7
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RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

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