<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection

ABSTRACT In a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016, http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of the Staphylococcus aureus protein clumping factor A (ClfA) in protecting mice from S. aureus infection. ClfA, one of the first proteins to...

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Autores principales:	Annaliesa S. Anderson, Ingrid L. Scully, Ed T. Buurman, Joseph Eiden, Kathrin U. Jansen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0ca0c311afcc44a8a27c7f51cbc2ade8
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spelling	oai:doaj.org-article:0ca0c311afcc44a8a27c7f51cbc2ade82021-11-15T15:41:42Z<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection10.1128/mBio.00225-162150-7511https://doaj.org/article/0ca0c311afcc44a8a27c7f51cbc2ade82016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00225-16https://doaj.org/toc/2150-7511ABSTRACT In a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016, http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of the Staphylococcus aureus protein clumping factor A (ClfA) in protecting mice from S. aureus infection. ClfA, one of the first proteins to be identified as a potential vaccine antigen for S. aureus prophylaxis, is currently a component of several investigational vaccines. The authors conclude that ClfA may not be effective for S. aureus prophylaxis. In contrast, previously published papers reporting positive data suggested that ClfA was potentially an important vaccine target to prevent invasive S. aureus disease. This commentary addresses the observed differences between the findings of Li et al. and those from other publications, highlighting the importance for preclinical vaccine antigen assessments to reflect the biological role of said antigen in virulence and, consequently, the importance of choosing appropriate preclinical disease models to test such antigens.Annaliesa S. AndersonIngrid L. ScullyEd T. BuurmanJoseph EidenKathrin U. JansenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Annaliesa S. Anderson Ingrid L. Scully Ed T. Buurman Joseph Eiden Kathrin U. Jansen <named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
description	ABSTRACT In a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016, http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of the Staphylococcus aureus protein clumping factor A (ClfA) in protecting mice from S. aureus infection. ClfA, one of the first proteins to be identified as a potential vaccine antigen for S. aureus prophylaxis, is currently a component of several investigational vaccines. The authors conclude that ClfA may not be effective for S. aureus prophylaxis. In contrast, previously published papers reporting positive data suggested that ClfA was potentially an important vaccine target to prevent invasive S. aureus disease. This commentary addresses the observed differences between the findings of Li et al. and those from other publications, highlighting the importance for preclinical vaccine antigen assessments to reflect the biological role of said antigen in virulence and, consequently, the importance of choosing appropriate preclinical disease models to test such antigens.
format	article
author	Annaliesa S. Anderson Ingrid L. Scully Ed T. Buurman Joseph Eiden Kathrin U. Jansen
author_facet	Annaliesa S. Anderson Ingrid L. Scully Ed T. Buurman Joseph Eiden Kathrin U. Jansen
author_sort	Annaliesa S. Anderson
title	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
title_short	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
title_full	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
title_fullStr	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
title_full_unstemmed	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection
title_sort	<named-content content-type="genus-species">staphylococcus aureus</named-content> clumping factor a remains a viable vaccine target for prevention of <named-content content-type="genus-species">s. aureus</named-content> infection
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/0ca0c311afcc44a8a27c7f51cbc2ade8
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<named-content content-type="genus-species">Staphylococcus aureus</named-content> Clumping Factor A Remains a Viable Vaccine Target for Prevention of <named-content content-type="genus-species">S. aureus</named-content> Infection

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