Washing with alkaline solutions in protein A purification improves physicochemical properties of monoclonal antibodies

Abstract Protein A affinity chromatography has been widely used for both laboratory scale purification and commercial manufacturing of monoclonal antibodies and Fc-fusion proteins. Protein A purification is specific and efficient. However, there still remain several issues to be addressed, such as i...

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Autores principales: Yuichi Imura, Toshiaki Tagawa, Yuya Miyamoto, Satoshi Nonoyama, Hiroshi Sumichika, Yasuhiro Fujino, Masaya Yamanouchi, Hideo Miki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0ca246364b864224b7da37a28cf7a642
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