A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report

Abstract Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We pres...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margaux Boistault, Mireia Lopez Corbeto, Pierre Quartier, Laura Berbel Arcobé, Ariadna Carsi Durall, Florence A. Aeschlimann
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Polyarteritis nodosa Child Tocilizumab Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/0ca2c184ab974bdbbfd6513f2594ed36
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ca2c184ab974bdbbfd6513f2594ed36
record_format	dspace
spelling	oai:doaj.org-article:0ca2c184ab974bdbbfd6513f2594ed362021-12-05T12:04:36ZA young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report10.1186/s12969-021-00654-71546-0096https://doaj.org/article/0ca2c184ab974bdbbfd6513f2594ed362021-12-01T00:00:00Zhttps://doi.org/10.1186/s12969-021-00654-7https://doaj.org/toc/1546-0096Abstract Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN.Margaux BoistaultMireia Lopez CorbetoPierre QuartierLaura Berbel ArcobéAriadna Carsi DurallFlorence A. AeschlimannBMCarticlePolyarteritis nodosaChildTocilizumabPediatricsRJ1-570Diseases of the musculoskeletal systemRC925-935ENPediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polyarteritis nodosa Child Tocilizumab Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
spellingShingle	Polyarteritis nodosa Child Tocilizumab Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935 Margaux Boistault Mireia Lopez Corbeto Pierre Quartier Laura Berbel Arcobé Ariadna Carsi Durall Florence A. Aeschlimann A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
description	Abstract Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN.
format	article
author	Margaux Boistault Mireia Lopez Corbeto Pierre Quartier Laura Berbel Arcobé Ariadna Carsi Durall Florence A. Aeschlimann
author_facet	Margaux Boistault Mireia Lopez Corbeto Pierre Quartier Laura Berbel Arcobé Ariadna Carsi Durall Florence A. Aeschlimann
author_sort	Margaux Boistault
title	A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
title_short	A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
title_full	A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
title_fullStr	A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
title_full_unstemmed	A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
title_sort	young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0ca2c184ab974bdbbfd6513f2594ed36
work_keys_str_mv	AT margauxboistault ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT mireialopezcorbeto ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT pierrequartier ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT lauraberbelarcobe ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT ariadnacarsidurall ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT florenceaaeschlimann ayounggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT margauxboistault younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT mireialopezcorbeto younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT pierrequartier younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT lauraberbelarcobe younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT ariadnacarsidurall younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport AT florenceaaeschlimann younggirlwithseverepolyarteritisnodosasuccessfullytreatedwithtocilizumabacasereport
_version_	1718372236847480832

A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report

Ejemplares similares