mTOR-dependent phosphorylation controls TFEB nuclear export

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.

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Autores principales:	Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ca34c106f93485d8615cf33135d22a2
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spelling	oai:doaj.org-article:0ca34c106f93485d8615cf33135d22a22021-12-02T16:56:43ZmTOR-dependent phosphorylation controls TFEB nuclear export10.1038/s41467-018-05862-62041-1723https://doaj.org/article/0ca34c106f93485d8615cf33135d22a22018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05862-6https://doaj.org/toc/2041-1723On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.Gennaro NapolitanoAlessandra EspositoHeejun ChoiMaria MatareseValerio BenedettiChiara Di MaltaJlenia MonfregolaDiego Luis MedinaJennifer Lippincott-SchwartzAndrea BallabioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gennaro Napolitano Alessandra Esposito Heejun Choi Maria Matarese Valerio Benedetti Chiara Di Malta Jlenia Monfregola Diego Luis Medina Jennifer Lippincott-Schwartz Andrea Ballabio mTOR-dependent phosphorylation controls TFEB nuclear export
description	On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.
format	article
author	Gennaro Napolitano Alessandra Esposito Heejun Choi Maria Matarese Valerio Benedetti Chiara Di Malta Jlenia Monfregola Diego Luis Medina Jennifer Lippincott-Schwartz Andrea Ballabio
author_facet	Gennaro Napolitano Alessandra Esposito Heejun Choi Maria Matarese Valerio Benedetti Chiara Di Malta Jlenia Monfregola Diego Luis Medina Jennifer Lippincott-Schwartz Andrea Ballabio
author_sort	Gennaro Napolitano
title	mTOR-dependent phosphorylation controls TFEB nuclear export
title_short	mTOR-dependent phosphorylation controls TFEB nuclear export
title_full	mTOR-dependent phosphorylation controls TFEB nuclear export
title_fullStr	mTOR-dependent phosphorylation controls TFEB nuclear export
title_full_unstemmed	mTOR-dependent phosphorylation controls TFEB nuclear export
title_sort	mtor-dependent phosphorylation controls tfeb nuclear export
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0ca34c106f93485d8615cf33135d22a2
work_keys_str_mv	AT gennaronapolitano mtordependentphosphorylationcontrolstfebnuclearexport AT alessandraesposito mtordependentphosphorylationcontrolstfebnuclearexport AT heejunchoi mtordependentphosphorylationcontrolstfebnuclearexport AT mariamatarese mtordependentphosphorylationcontrolstfebnuclearexport AT valeriobenedetti mtordependentphosphorylationcontrolstfebnuclearexport AT chiaradimalta mtordependentphosphorylationcontrolstfebnuclearexport AT jleniamonfregola mtordependentphosphorylationcontrolstfebnuclearexport AT diegoluismedina mtordependentphosphorylationcontrolstfebnuclearexport AT jenniferlippincottschwartz mtordependentphosphorylationcontrolstfebnuclearexport AT andreaballabio mtordependentphosphorylationcontrolstfebnuclearexport
_version_	1718382722885353472

mTOR-dependent phosphorylation controls TFEB nuclear export

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