Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

Background: Exercise can protect myocardial infarction (MI) and downregulate cardiac Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is unclear. Methods: HIPK2–/– mice and miR-222–/– rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) carryin...

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Autores principales: Qiulian Zhou, Jiali Deng, Jianhua Yao, Jiaxin Song, Danni Meng, Yujiao Zhu, Minjun Xu, Yajun Liang, Jiahong Xu, Joost PG Sluijter, Junjie Xiao
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/0ca37ec124dc49cdadbe6ad4e0e1f44c
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