Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone
The histone variant mutation H3.3-G34W occurs in the majority of giant cell tumor of bone (GCTB). By profiling patient-derived GCTB tumor cells, the authors show that this mutation associates with epigenetic alterations in heterochromatic and bivalent regions that contribute to an impaired osteogeni...
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2020
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oai:doaj.org-article:0ca3a08070bf40f2a72b5ae76155d70a2021-12-02T17:33:14ZGlobally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone10.1038/s41467-020-18955-y2041-1723https://doaj.org/article/0ca3a08070bf40f2a72b5ae76155d70a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18955-yhttps://doaj.org/toc/2041-1723The histone variant mutation H3.3-G34W occurs in the majority of giant cell tumor of bone (GCTB). By profiling patient-derived GCTB tumor cells, the authors show that this mutation associates with epigenetic alterations in heterochromatic and bivalent regions that contribute to an impaired osteogenic differentiation and the osteolytic phenotype of GCTB.Pavlo LutsikAnnika BaudeDaniela MancarellaSimin ÖzAlexander KühnReka TothJoschka HeyUmut H. ToprakJinyeong LimViet Ha NguyenChao JiangAnand MayakondaMark HartmannFelix RosemannKersten BreuerDominik VonfichtFlorian GrünschlägerSuman LeeMaren Kirstin SchuhmacherDenis KusevicAnna JauchDieter WeichenhanJozef ZustinMatthias SchlesnerSimon HaasJoo Hyun ParkYoon Jung ParkUdo OppermannAlbert JeltschFlorian HallerJörg FellenbergAnders M. LindrothChristoph PlassNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Pavlo Lutsik Annika Baude Daniela Mancarella Simin Öz Alexander Kühn Reka Toth Joschka Hey Umut H. Toprak Jinyeong Lim Viet Ha Nguyen Chao Jiang Anand Mayakonda Mark Hartmann Felix Rosemann Kersten Breuer Dominik Vonficht Florian Grünschläger Suman Lee Maren Kirstin Schuhmacher Denis Kusevic Anna Jauch Dieter Weichenhan Jozef Zustin Matthias Schlesner Simon Haas Joo Hyun Park Yoon Jung Park Udo Oppermann Albert Jeltsch Florian Haller Jörg Fellenberg Anders M. Lindroth Christoph Plass Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| description |
The histone variant mutation H3.3-G34W occurs in the majority of giant cell tumor of bone (GCTB). By profiling patient-derived GCTB tumor cells, the authors show that this mutation associates with epigenetic alterations in heterochromatic and bivalent regions that contribute to an impaired osteogenic differentiation and the osteolytic phenotype of GCTB. |
| format |
article |
| author |
Pavlo Lutsik Annika Baude Daniela Mancarella Simin Öz Alexander Kühn Reka Toth Joschka Hey Umut H. Toprak Jinyeong Lim Viet Ha Nguyen Chao Jiang Anand Mayakonda Mark Hartmann Felix Rosemann Kersten Breuer Dominik Vonficht Florian Grünschläger Suman Lee Maren Kirstin Schuhmacher Denis Kusevic Anna Jauch Dieter Weichenhan Jozef Zustin Matthias Schlesner Simon Haas Joo Hyun Park Yoon Jung Park Udo Oppermann Albert Jeltsch Florian Haller Jörg Fellenberg Anders M. Lindroth Christoph Plass |
| author_facet |
Pavlo Lutsik Annika Baude Daniela Mancarella Simin Öz Alexander Kühn Reka Toth Joschka Hey Umut H. Toprak Jinyeong Lim Viet Ha Nguyen Chao Jiang Anand Mayakonda Mark Hartmann Felix Rosemann Kersten Breuer Dominik Vonficht Florian Grünschläger Suman Lee Maren Kirstin Schuhmacher Denis Kusevic Anna Jauch Dieter Weichenhan Jozef Zustin Matthias Schlesner Simon Haas Joo Hyun Park Yoon Jung Park Udo Oppermann Albert Jeltsch Florian Haller Jörg Fellenberg Anders M. Lindroth Christoph Plass |
| author_sort |
Pavlo Lutsik |
| title |
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| title_short |
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| title_full |
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| title_fullStr |
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| title_full_unstemmed |
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone |
| title_sort |
globally altered epigenetic landscape and delayed osteogenic differentiation in h3.3-g34w-mutant giant cell tumor of bone |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0ca3a08070bf40f2a72b5ae76155d70a |
| work_keys_str_mv |
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