Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study

Rui Peng, Yan Li Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of ChinaCorrespondence: Yan LiDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, People’s Republ...

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Autores principales:	Peng R, Li Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	tenascin-c testosterone major depressive disorder Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0ca5ed992c2442eea486bfb12d188a42
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spelling	oai:doaj.org-article:0ca5ed992c2442eea486bfb12d188a422021-12-02T18:23:04ZAssociations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study1178-7031https://doaj.org/article/0ca5ed992c2442eea486bfb12d188a422021-03-01T00:00:00Zhttps://www.dovepress.com/associations-between-tenascin-c-and-testosterone-deficiency-in-men-wit-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Rui Peng, Yan Li Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of ChinaCorrespondence: Yan LiDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, People’s Republic of ChinaTel +86 2788071553Email pengruiwec@163.comBackground: Elevated levels of tenascin-C are linked to increased risk and severity of major depressive disorder (MDD), while testosterone shows a protective effect. The present study explored associations between serum levels of tenascin-C and testosterone in Chinese men with MDD.Methods: Testosterone and tenascin-C levels were measured in sera of 412 men with MDD and 237 age- and sex-matched controls. Serum levels of thyroid hormone, lipids, and high-sensitivity C-reactive protein (hs-CRP) were also quantified. Potential associations were examined using covariance, subgroup analysis, and multivariate linear regression analyses.Results: Significantly higher concentrations of tenascin-C were detected in sera of subjects with MDD than in controls. Among subjects with MDD, testosterone concentrations inversely correlated with tenascin-C levels. This relationship was observed when patients were stratified by age at onset; duration or severity of depression; or concentration of thyroid hormones, low- or high-density lipoprotein, or hs-CRP. The negative association remained even when the statistical model was adjusted for age, smoking status, alcohol use, and body mass index. Linear regression with bootstrap resampling confirmed that high tenascin-C levels inversely correlated with testosterone levels.Conclusion: In men with MDD, high tenascin-C concentrations correlate with testosterone deficiency. The combination of elevated tenascin-C and testosterone deficiency may be associated with MDD progression.Keywords: tenascin-C, testosterone, major depressive disorderPeng RLi YDove Medical Pressarticletenascin-ctestosteronemajor depressive disorderPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 897-905 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tenascin-c testosterone major depressive disorder Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	tenascin-c testosterone major depressive disorder Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Peng R Li Y Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
description	Rui Peng, Yan Li Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of ChinaCorrespondence: Yan LiDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, People’s Republic of ChinaTel +86 2788071553Email pengruiwec@163.comBackground: Elevated levels of tenascin-C are linked to increased risk and severity of major depressive disorder (MDD), while testosterone shows a protective effect. The present study explored associations between serum levels of tenascin-C and testosterone in Chinese men with MDD.Methods: Testosterone and tenascin-C levels were measured in sera of 412 men with MDD and 237 age- and sex-matched controls. Serum levels of thyroid hormone, lipids, and high-sensitivity C-reactive protein (hs-CRP) were also quantified. Potential associations were examined using covariance, subgroup analysis, and multivariate linear regression analyses.Results: Significantly higher concentrations of tenascin-C were detected in sera of subjects with MDD than in controls. Among subjects with MDD, testosterone concentrations inversely correlated with tenascin-C levels. This relationship was observed when patients were stratified by age at onset; duration or severity of depression; or concentration of thyroid hormones, low- or high-density lipoprotein, or hs-CRP. The negative association remained even when the statistical model was adjusted for age, smoking status, alcohol use, and body mass index. Linear regression with bootstrap resampling confirmed that high tenascin-C levels inversely correlated with testosterone levels.Conclusion: In men with MDD, high tenascin-C concentrations correlate with testosterone deficiency. The combination of elevated tenascin-C and testosterone deficiency may be associated with MDD progression.Keywords: tenascin-C, testosterone, major depressive disorder
format	article
author	Peng R Li Y
author_facet	Peng R Li Y
author_sort	Peng R
title	Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
title_short	Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
title_full	Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
title_fullStr	Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
title_full_unstemmed	Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
title_sort	associations between tenascin-c and testosterone deficiency in men with major depressive disorder: a cross-sectional retrospective study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0ca5ed992c2442eea486bfb12d188a42
work_keys_str_mv	AT pengr associationsbetweentenascincandtestosteronedeficiencyinmenwithmajordepressivedisorderacrosssectionalretrospectivestudy AT liy associationsbetweentenascincandtestosteronedeficiencyinmenwithmajordepressivedisorderacrosssectionalretrospectivestudy
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Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study

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