Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Abstract Due to the lack of efficacy of synthetic vascular substitutes in the replacement of small-caliber arteries, vascular tissue engineering (VTE) has emerged as a promising solution to produce viable small-caliber tissue-engineered vascular grafts (TEVG). Previous studies have shown the importa...

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Autores principales:	Adrien Fayon, Patrick Menu, Reine El Omar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/0ca98b3dacd64e58b3db5aa59f2accbe
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spelling	oai:doaj.org-article:0ca98b3dacd64e58b3db5aa59f2accbe2021-12-02T18:50:54ZCellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard10.1038/s41536-021-00155-x2057-3995https://doaj.org/article/0ca98b3dacd64e58b3db5aa59f2accbe2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00155-xhttps://doaj.org/toc/2057-3995Abstract Due to the lack of efficacy of synthetic vascular substitutes in the replacement of small-caliber arteries, vascular tissue engineering (VTE) has emerged as a promising solution to produce viable small-caliber tissue-engineered vascular grafts (TEVG). Previous studies have shown the importance of a cellular intimal layer at the luminal surface of TEVG to prevent thrombotic events. However, the cellularization of a TEVG seems to be a critical approach to consider in the development of a TEVG. To date, no standard cellularization method or cell type has been established to create the ideal TEVG by promoting its long-term patency and function. In this review, advances in VTE are described and discussed with a particular focus on the construction approaches of cellularized small-caliber TEVGs, the cell types used, as well as their preclinical and clinical applications.Adrien FayonPatrick MenuReine El OmarNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Adrien Fayon Patrick Menu Reine El Omar Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
description	Abstract Due to the lack of efficacy of synthetic vascular substitutes in the replacement of small-caliber arteries, vascular tissue engineering (VTE) has emerged as a promising solution to produce viable small-caliber tissue-engineered vascular grafts (TEVG). Previous studies have shown the importance of a cellular intimal layer at the luminal surface of TEVG to prevent thrombotic events. However, the cellularization of a TEVG seems to be a critical approach to consider in the development of a TEVG. To date, no standard cellularization method or cell type has been established to create the ideal TEVG by promoting its long-term patency and function. In this review, advances in VTE are described and discussed with a particular focus on the construction approaches of cellularized small-caliber TEVGs, the cell types used, as well as their preclinical and clinical applications.
format	article
author	Adrien Fayon Patrick Menu Reine El Omar
author_facet	Adrien Fayon Patrick Menu Reine El Omar
author_sort	Adrien Fayon
title	Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
title_short	Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
title_full	Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
title_fullStr	Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
title_full_unstemmed	Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
title_sort	cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0ca98b3dacd64e58b3db5aa59f2accbe
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Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

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