Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

<i>Background and Objectives</i>: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics target plasma apurinic apyrimid...

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Autores principales:	Yumin Jo, Yeojung Kim, Eunhye Park, Yuran Lee, Jiyeon Kim, Minwoong Kang, Jaesung Lim, Insang Song, Chaeseong Lim, Byeonghwa Jeon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anesthesia APEX1 protein cancer propofol surgery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0cad6d98ded14089bc3b7d0752badb96
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spelling	oai:doaj.org-article:0cad6d98ded14089bc3b7d0752badb962021-11-25T18:19:12ZChanges in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study10.3390/medicina571112801648-91441010-660Xhttps://doaj.org/article/0cad6d98ded14089bc3b7d0752badb962021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1280https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics target plasma apurinic apyrimidinic endonuclease/redox effector factor-1 (APE1/Ref-1) as a possible mechanism of action. <i>Materials and Methods</i>: The plasma APE1/Ref-1 level was evaluated three times during surgery for cancer, i.e., before anesthesia, immediately after cancer resection, and finally, in the recovery room. Blood (3 cc) was drawn from the radial artery catheter, and plasma APE1/Ref-1 levels were compared according to measurement time and between the two groups. Spearman’s Rho correlation analysis was performed to determine relationships among body mass index, American Society of Anesthesiologists classification, age, sex, cancer type, and tumor-node-metastasis (TNM) stage. A total of 166 patients (VIA: 129; TIVA: 37) were enrolled. <i>Results</i>: Plasma APE1/Ref-1 level increased significantly (<i>p</i> = 0.028) after cancer resection compared with before surgery, but no significant difference was observed between anesthetics (<i>p</i> = 0.134). The post-resection plasma APE1/Ref-1 level showed a positive correlation with the NM stages, but not the T stage. <i>Conclusions</i>: The plasma APE1/Ref-1 level increased during surgery with more severe lymph node invasion, but there were no significant differences according to the anesthetics used.Yumin JoYeojung KimEunhye ParkYuran LeeJiyeon KimMinwoong KangJaesung LimInsang SongChaeseong LimByeonghwa JeonMDPI AGarticleanesthesiaAPEX1 proteincancerpropofolsurgeryMedicine (General)R5-920ENMedicina, Vol 57, Iss 1280, p 1280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anesthesia APEX1 protein cancer propofol surgery Medicine (General) R5-920
spellingShingle	anesthesia APEX1 protein cancer propofol surgery Medicine (General) R5-920 Yumin Jo Yeojung Kim Eunhye Park Yuran Lee Jiyeon Kim Minwoong Kang Jaesung Lim Insang Song Chaeseong Lim Byeonghwa Jeon Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
description	<i>Background and Objectives</i>: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics target plasma apurinic apyrimidinic endonuclease/redox effector factor-1 (APE1/Ref-1) as a possible mechanism of action. <i>Materials and Methods</i>: The plasma APE1/Ref-1 level was evaluated three times during surgery for cancer, i.e., before anesthesia, immediately after cancer resection, and finally, in the recovery room. Blood (3 cc) was drawn from the radial artery catheter, and plasma APE1/Ref-1 levels were compared according to measurement time and between the two groups. Spearman’s Rho correlation analysis was performed to determine relationships among body mass index, American Society of Anesthesiologists classification, age, sex, cancer type, and tumor-node-metastasis (TNM) stage. A total of 166 patients (VIA: 129; TIVA: 37) were enrolled. <i>Results</i>: Plasma APE1/Ref-1 level increased significantly (<i>p</i> = 0.028) after cancer resection compared with before surgery, but no significant difference was observed between anesthetics (<i>p</i> = 0.134). The post-resection plasma APE1/Ref-1 level showed a positive correlation with the NM stages, but not the T stage. <i>Conclusions</i>: The plasma APE1/Ref-1 level increased during surgery with more severe lymph node invasion, but there were no significant differences according to the anesthetics used.
format	article
author	Yumin Jo Yeojung Kim Eunhye Park Yuran Lee Jiyeon Kim Minwoong Kang Jaesung Lim Insang Song Chaeseong Lim Byeonghwa Jeon
author_facet	Yumin Jo Yeojung Kim Eunhye Park Yuran Lee Jiyeon Kim Minwoong Kang Jaesung Lim Insang Song Chaeseong Lim Byeonghwa Jeon
author_sort	Yumin Jo
title	Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
title_short	Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
title_full	Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
title_fullStr	Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
title_full_unstemmed	Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study
title_sort	changes in the plasma apurinic/apyrimidinic endonuclease 1/redox factor-1(ape1/ref-1) level during cancer surgery: an observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0cad6d98ded14089bc3b7d0752badb96
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Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

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