Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature

Lei Deng,1 Janaki Sharma,2 Elizabeth Ravera,2 Balazs Halmos,2 Haiying Cheng2 1Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA; 2Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA Abstract: Alectinib...

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Autores principales:	Deng L, Sharma J, Ravera E, Halmos B, Cheng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hypersensitivity ALK alectinib brigatinib lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0caebd19853b40e79ff778c3c345caa1
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spelling	oai:doaj.org-article:0caebd19853b40e79ff778c3c345caa12021-12-02T00:36:25ZHypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature1179-2728https://doaj.org/article/0caebd19853b40e79ff778c3c345caa12018-09-01T00:00:00Zhttps://www.dovepress.com/hypersensitivity-in-alk-positive-lung-cancers-exposed-to-alk-inhibitor-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Lei Deng,1 Janaki Sharma,2 Elizabeth Ravera,2 Balazs Halmos,2 Haiying Cheng2 1Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA; 2Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA Abstract: Alectinib can cause rare, but severe hypersensitivity. The cross-reactivity between different ALK inhibitors is unknown and desensitization is the only reported management. We hereby report the first case of severe delayed hypersensitivity developed in a lung cancer patient treated by alectinib, who was successfully managed by switching to brigatinib, another ALK inhibitor. The patient achieved excellent anti-tumor response to brigatinib. Our case provides an alternative and safe strategy in patients with alectinib-related hypersensitivity. Keywords: alectinib, brigatinibDeng LSharma JRavera EHalmos BCheng HDove Medical PressarticleHypersensitivityALKalectinibbrigatiniblung cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 9, Pp 73-77 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypersensitivity ALK alectinib brigatinib lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Hypersensitivity ALK alectinib brigatinib lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Deng L Sharma J Ravera E Halmos B Cheng H Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
description	Lei Deng,1 Janaki Sharma,2 Elizabeth Ravera,2 Balazs Halmos,2 Haiying Cheng2 1Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA; 2Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA Abstract: Alectinib can cause rare, but severe hypersensitivity. The cross-reactivity between different ALK inhibitors is unknown and desensitization is the only reported management. We hereby report the first case of severe delayed hypersensitivity developed in a lung cancer patient treated by alectinib, who was successfully managed by switching to brigatinib, another ALK inhibitor. The patient achieved excellent anti-tumor response to brigatinib. Our case provides an alternative and safe strategy in patients with alectinib-related hypersensitivity. Keywords: alectinib, brigatinib
format	article
author	Deng L Sharma J Ravera E Halmos B Cheng H
author_facet	Deng L Sharma J Ravera E Halmos B Cheng H
author_sort	Deng L
title	Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
title_short	Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
title_full	Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
title_fullStr	Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
title_full_unstemmed	Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature
title_sort	hypersensitivity in alk-positive lung cancers exposed to alk inhibitors: a case of successful switch to an alternative alk inhibitor and systematic review of the literature
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0caebd19853b40e79ff778c3c345caa1
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Hypersensitivity in ALK-positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature

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