Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

Devasier Bennet,1 Mohana Marimuthu,1 Sanghyo Kim,1 Jeongho An21Department of Bionanotechnology, Gachon University, Gyeonggi, Republic of Korea; 2Department of Polymer Science and Engineering, SunKyunKwan University, Gyeonggi, Republic of KoreaAbstract: Antioxidant (quercetin) and hypoglycemic (vogli...

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Autores principales:	Bennet D, Marimuthu M, Kim S, An J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0cb0178dd36c43fcbd3a52fb0c26a3e6
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spelling	oai:doaj.org-article:0cb0178dd36c43fcbd3a52fb0c26a3e62021-12-02T00:40:16ZDual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery1176-91141178-2013https://doaj.org/article/0cb0178dd36c43fcbd3a52fb0c26a3e62012-07-01T00:00:00Zhttp://www.dovepress.com/dual-drug-loaded-nanoparticles-on-self-integrated-scaffold-for-control-a10415https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Devasier Bennet,1 Mohana Marimuthu,1 Sanghyo Kim,1 Jeongho An21Department of Bionanotechnology, Gachon University, Gyeonggi, Republic of Korea; 2Department of Polymer Science and Engineering, SunKyunKwan University, Gyeonggi, Republic of KoreaAbstract: Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactide-co-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of the film formulation were achieved utilizing several ratios of excipients, including polyvinyl alcohol, polyethylene glycol, hyaluronic acid, xylitol, and alginate. The scaffold film showed superior encapsulation capability and swelling properties, with various potential applications, eg, the treatment of diabetes-associated complications. Structural and light scattering characterization confirmed a spherical shape and a mean particle size distribution of 41.3 nm for nanoparticles in the scaffold film. Spectroscopy revealed a stable polymer structure before and after encapsulation. The thermoresponsive swelling properties of the film were evaluated according to temperature and pH. Scaffold films incorporating dual drug-loaded nanoparticles showed remarkably high thermoresponsivity, cell compatibility, and ex vivo drug-release behavior. In addition, the hybrid film formulation showed enhanced cell adhesion and proliferation. These dual drug-loaded nanoparticles incorporated into a scaffold film may be promising for development into a transdermal drug-delivery system.Keywords: quercetin, voglibose, biocompatible materials, encapsulation, transdermalBennet DMarimuthu MKim SAn JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3399-3419 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Bennet D Marimuthu M Kim S An J Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
description	Devasier Bennet,1 Mohana Marimuthu,1 Sanghyo Kim,1 Jeongho An21Department of Bionanotechnology, Gachon University, Gyeonggi, Republic of Korea; 2Department of Polymer Science and Engineering, SunKyunKwan University, Gyeonggi, Republic of KoreaAbstract: Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactide-co-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of the film formulation were achieved utilizing several ratios of excipients, including polyvinyl alcohol, polyethylene glycol, hyaluronic acid, xylitol, and alginate. The scaffold film showed superior encapsulation capability and swelling properties, with various potential applications, eg, the treatment of diabetes-associated complications. Structural and light scattering characterization confirmed a spherical shape and a mean particle size distribution of 41.3 nm for nanoparticles in the scaffold film. Spectroscopy revealed a stable polymer structure before and after encapsulation. The thermoresponsive swelling properties of the film were evaluated according to temperature and pH. Scaffold films incorporating dual drug-loaded nanoparticles showed remarkably high thermoresponsivity, cell compatibility, and ex vivo drug-release behavior. In addition, the hybrid film formulation showed enhanced cell adhesion and proliferation. These dual drug-loaded nanoparticles incorporated into a scaffold film may be promising for development into a transdermal drug-delivery system.Keywords: quercetin, voglibose, biocompatible materials, encapsulation, transdermal
format	article
author	Bennet D Marimuthu M Kim S An J
author_facet	Bennet D Marimuthu M Kim S An J
author_sort	Bennet D
title	Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
title_short	Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
title_full	Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
title_fullStr	Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
title_full_unstemmed	Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
title_sort	dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/0cb0178dd36c43fcbd3a52fb0c26a3e6
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Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

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