The IAP family member BRUCE regulates autophagosome–lysosome fusion

The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.

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Autores principales: Petra Ebner, Isabella Poetsch, Luiza Deszcz, Thomas Hoffmann, Johannes Zuber, Fumiyo Ikeda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0cb3000d28fd4baf9835044b1be98747
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spelling oai:doaj.org-article:0cb3000d28fd4baf9835044b1be987472021-12-02T16:50:09ZThe IAP family member BRUCE regulates autophagosome–lysosome fusion10.1038/s41467-018-02823-x2041-1723https://doaj.org/article/0cb3000d28fd4baf9835044b1be987472018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02823-xhttps://doaj.org/toc/2041-1723The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.Petra EbnerIsabella PoetschLuiza DeszczThomas HoffmannJohannes ZuberFumiyo IkedaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Petra Ebner
Isabella Poetsch
Luiza Deszcz
Thomas Hoffmann
Johannes Zuber
Fumiyo Ikeda
The IAP family member BRUCE regulates autophagosome–lysosome fusion
description The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.
format article
author Petra Ebner
Isabella Poetsch
Luiza Deszcz
Thomas Hoffmann
Johannes Zuber
Fumiyo Ikeda
author_facet Petra Ebner
Isabella Poetsch
Luiza Deszcz
Thomas Hoffmann
Johannes Zuber
Fumiyo Ikeda
author_sort Petra Ebner
title The IAP family member BRUCE regulates autophagosome–lysosome fusion
title_short The IAP family member BRUCE regulates autophagosome–lysosome fusion
title_full The IAP family member BRUCE regulates autophagosome–lysosome fusion
title_fullStr The IAP family member BRUCE regulates autophagosome–lysosome fusion
title_full_unstemmed The IAP family member BRUCE regulates autophagosome–lysosome fusion
title_sort iap family member bruce regulates autophagosome–lysosome fusion
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0cb3000d28fd4baf9835044b1be98747
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