The IAP family member BRUCE regulates autophagosome–lysosome fusion
The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.
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Nature Portfolio
2018
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oai:doaj.org-article:0cb3000d28fd4baf9835044b1be987472021-12-02T16:50:09ZThe IAP family member BRUCE regulates autophagosome–lysosome fusion10.1038/s41467-018-02823-x2041-1723https://doaj.org/article/0cb3000d28fd4baf9835044b1be987472018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02823-xhttps://doaj.org/toc/2041-1723The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.Petra EbnerIsabella PoetschLuiza DeszczThomas HoffmannJohannes ZuberFumiyo IkedaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Petra Ebner Isabella Poetsch Luiza Deszcz Thomas Hoffmann Johannes Zuber Fumiyo Ikeda The IAP family member BRUCE regulates autophagosome–lysosome fusion |
description |
The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion. |
format |
article |
author |
Petra Ebner Isabella Poetsch Luiza Deszcz Thomas Hoffmann Johannes Zuber Fumiyo Ikeda |
author_facet |
Petra Ebner Isabella Poetsch Luiza Deszcz Thomas Hoffmann Johannes Zuber Fumiyo Ikeda |
author_sort |
Petra Ebner |
title |
The IAP family member BRUCE regulates autophagosome–lysosome fusion |
title_short |
The IAP family member BRUCE regulates autophagosome–lysosome fusion |
title_full |
The IAP family member BRUCE regulates autophagosome–lysosome fusion |
title_fullStr |
The IAP family member BRUCE regulates autophagosome–lysosome fusion |
title_full_unstemmed |
The IAP family member BRUCE regulates autophagosome–lysosome fusion |
title_sort |
iap family member bruce regulates autophagosome–lysosome fusion |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/0cb3000d28fd4baf9835044b1be98747 |
work_keys_str_mv |
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1718383081287581696 |