Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants

Abstract The improvement of delivery room care, according to the 2015 International Consensus, may affect neonatal outcome, especially in very-low-birth-weight infants. We aimed to investigate the current practice of neonatal resuscitation by year and analyze the association with neonatal outcomes....

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Autores principales:	So Jin Yoon, Joohee Lim, Jung Ho Han, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Kook In Park, Soon Min Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cb4c1ff88ed4a48b1fec42686c2e371
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spelling	oai:doaj.org-article:0cb4c1ff88ed4a48b1fec42686c2e3712021-12-02T17:14:58ZImpact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants10.1038/s41598-021-88561-52045-2322https://doaj.org/article/0cb4c1ff88ed4a48b1fec42686c2e3712021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88561-5https://doaj.org/toc/2045-2322Abstract The improvement of delivery room care, according to the 2015 International Consensus, may affect neonatal outcome, especially in very-low-birth-weight infants. We aimed to investigate the current practice of neonatal resuscitation by year and analyze the association with neonatal outcomes. A total of 8142 very-low-birth-weight infants, registered in the Korean Neonatal Network between 2014 and 2017 were included. A significant decreasing trend of intubation (64.5% vs 55.1%, P < 0.0001) and markedly increasing trend of positive pressure ventilation (PPV) (11.5% vs 22.9%, P < 0.0001) were noted. The annual PPV rate differed significantly by gestation (P < 0.0001). The highest level of resuscitation was also shown as an independent risk factor for mortality within 7 days and for bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and periventricular leukomalacia. PPV and intubation were associated with significantly decreased risk of mortality and morbidities compared to epinephrine use. When considering association, the incidence of mortality within 7 days, IVH, PVL, and BPD or mortality showed significant differences by combination of year, gestational age, and level of resuscitation. According to updated guidelines, changes in the highest level of resuscitation significantly associated with reducing mortality and morbidities. More meticulous delivery room resuscitation focusing on extreme prematurity is needed.So Jin YoonJoohee LimJung Ho HanJeong Eun ShinHo Seon EunMin Soo ParkKook In ParkSoon Min LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So Jin Yoon Joohee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo Park Kook In Park Soon Min Lee Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
description	Abstract The improvement of delivery room care, according to the 2015 International Consensus, may affect neonatal outcome, especially in very-low-birth-weight infants. We aimed to investigate the current practice of neonatal resuscitation by year and analyze the association with neonatal outcomes. A total of 8142 very-low-birth-weight infants, registered in the Korean Neonatal Network between 2014 and 2017 were included. A significant decreasing trend of intubation (64.5% vs 55.1%, P < 0.0001) and markedly increasing trend of positive pressure ventilation (PPV) (11.5% vs 22.9%, P < 0.0001) were noted. The annual PPV rate differed significantly by gestation (P < 0.0001). The highest level of resuscitation was also shown as an independent risk factor for mortality within 7 days and for bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and periventricular leukomalacia. PPV and intubation were associated with significantly decreased risk of mortality and morbidities compared to epinephrine use. When considering association, the incidence of mortality within 7 days, IVH, PVL, and BPD or mortality showed significant differences by combination of year, gestational age, and level of resuscitation. According to updated guidelines, changes in the highest level of resuscitation significantly associated with reducing mortality and morbidities. More meticulous delivery room resuscitation focusing on extreme prematurity is needed.
format	article
author	So Jin Yoon Joohee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo Park Kook In Park Soon Min Lee
author_facet	So Jin Yoon Joohee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo Park Kook In Park Soon Min Lee
author_sort	So Jin Yoon
title	Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
title_short	Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
title_full	Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
title_fullStr	Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
title_full_unstemmed	Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
title_sort	impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0cb4c1ff88ed4a48b1fec42686c2e371
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Impact of neonatal resuscitation changes on outcomes of very-low-birth-weight infants

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