Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1

Shinji Makino, Hironobu Tampo, Yusuke Arai, Hiroto ObataDepartment of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, JapanAbstract: To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases...

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Autores principales:	Makino S, Tampo H, Arai Y, Obata H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0cb65be8f948450995420dd8dd822b91
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spelling	oai:doaj.org-article:0cb65be8f948450995420dd8dd822b912021-12-02T00:56:20ZCorrelations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 11177-5483https://doaj.org/article/0cb65be8f948450995420dd8dd822b912014-01-01T00:00:00Zhttp://www.dovepress.com/correlations-between-choroidal-abnormalities-lisch-nodules-and-age-in--a15409https://doaj.org/toc/1177-5483 Shinji Makino, Hironobu Tampo, Yusuke Arai, Hiroto ObataDepartment of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, JapanAbstract: To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. Patients ranged in age from 4 to 39 years. The angle used for near-infrared reflectance imaging was 55°. We counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and the total number of Lisch nodules on the iris by slit-lamp examination. No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P=0.7414). Choroidal abnormalities tended to increase with age (ρ=0.6150), but this difference was not statistically significant (P=0.0650). A positive correlation was found between the number of choroidal abnormalities and Lisch nodules (ρ=0.783, P=0.0267). In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules.Keywords: neurofibromatosis type 1, near-infrared reflectance, choroidal abnormality, Lisch nodule, ageMakino STampo HArai YObata HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 165-168 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Makino S Tampo H Arai Y Obata H Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
description	Shinji Makino, Hironobu Tampo, Yusuke Arai, Hiroto ObataDepartment of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, JapanAbstract: To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. Patients ranged in age from 4 to 39 years. The angle used for near-infrared reflectance imaging was 55°. We counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and the total number of Lisch nodules on the iris by slit-lamp examination. No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P=0.7414). Choroidal abnormalities tended to increase with age (ρ=0.6150), but this difference was not statistically significant (P=0.0650). A positive correlation was found between the number of choroidal abnormalities and Lisch nodules (ρ=0.783, P=0.0267). In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules.Keywords: neurofibromatosis type 1, near-infrared reflectance, choroidal abnormality, Lisch nodule, age
format	article
author	Makino S Tampo H Arai Y Obata H
author_facet	Makino S Tampo H Arai Y Obata H
author_sort	Makino S
title	Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
title_short	Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
title_full	Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
title_fullStr	Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
title_full_unstemmed	Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1
title_sort	correlations between choroidal abnormalities, lisch nodules, and age in patients with neurofibromatosis type 1
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0cb65be8f948450995420dd8dd822b91
work_keys_str_mv	AT makinos correlationsbetweenchoroidalabnormalitieslischnodulesandageinpatientswithneurofibromatosistype1 AT tampoh correlationsbetweenchoroidalabnormalitieslischnodulesandageinpatientswithneurofibromatosistype1 AT araiy correlationsbetweenchoroidalabnormalitieslischnodulesandageinpatientswithneurofibromatosistype1 AT obatah correlationsbetweenchoroidalabnormalitieslischnodulesandageinpatientswithneurofibromatosistype1
_version_	1718403359447187456

Correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1

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