A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.

<h4>Background</h4>When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons....

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Autores principales: John Simes, Merryn Voysey, Rachel O'Connell, Paul Glasziou, James D Best, Russell Scott, Christopher Pardy, Karen Byth, David R Sullivan, Christian Ehnholm, Anthony Keech, FIELD Study Investigators
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/0cb9474b245145e6887b5c789122e9ec
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