Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population

Chao Liu,1 Sijia Song,2 Junkai Zhang,1 Xiao Li,1 Huijie Gao1 1College of Pharmacy, Jining Medical University, Rizhao, Shandong, People’s Republic of China; 2Rizhao Mental Health Center, Rizhao, Shandong, People’s Republic of ChinaCorrespondence: Huijie GaoCollege of Pharmacy, Jin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu C, Song S, Zhang J, Li X, Gao H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	oxidative stress schizophrenia glutathione peroxidase glutathione s-transferase gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0cb9a96c353d47f7bd32477495af1027
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0cb9a96c353d47f7bd32477495af1027
record_format	dspace
spelling	oai:doaj.org-article:0cb9a96c353d47f7bd32477495af10272021-12-02T08:43:08ZEffects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population1178-2021https://doaj.org/article/0cb9a96c353d47f7bd32477495af10272020-01-01T00:00:00Zhttps://www.dovepress.com/effects-of-gsta1-and-gpx3-polymorphisms-on-the-risk-of-schizophrenia-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chao Liu,1 Sijia Song,2 Junkai Zhang,1 Xiao Li,1 Huijie Gao1 1College of Pharmacy, Jining Medical University, Rizhao, Shandong, People’s Republic of China; 2Rizhao Mental Health Center, Rizhao, Shandong, People’s Republic of ChinaCorrespondence: Huijie GaoCollege of Pharmacy, Jining Medical University, 669 Xueyuan Road, Rizhao 276826, People’s Republic of ChinaTel +86 15954014646Email mianyigao@163.comPurpose: Several lines of evidence support the fact that the presence of oxidative stress plays an important role in the pathophysiological mechanisms of schizophrenia (SCZ). The glutathione peroxidases (GPXs) and glutathione S-transferases (GSTs) are the major antioxidant enzymes. Polymorphic variants of GPX and GST can affect the antioxidant activities of their encoded enzymes. This study explored the possible associations of the GSTA1 and GPX3 gene polymorphisms and schizophrenia in Chinese Han population.Methods: DNA from 648 healthy controls and 617 schizophrenic patients was genotyped for single-nucleotide polymorphisms (SNPs) rs3957357 in GSTA1 and rs736775 in GPX3 using a PCR-LDR genotyping assay. The χ2 test compared differences in genetic distributions between the two groups in a case–control study. The generalized multifactor dimensionality reduction (GMDR) was used to explore the interaction between the GSTA1 gene and the GPX3 gene on the risk of SCZ.Results: Significant differences in allelic and genotypic frequencies of GSTA1 rs3957357 were present between SCZ and control groups (GSTA1 rs3957357 χ2=6.172, P=0.046 by genotype, χ2=5.847, P=0.016, odds ratio=1.329, 95% confidence interval=1.055–1.674 by allele). No significant differences in allelic or genotypic frequencies of GPX3 rs736775 were detected between cases and controls (GPX3 rs736775: χ2=2.058, P=0.357 by genotype, χ2=1.853, P=0.173, odds ratio=1.131, 95% confidence interval=0.953–1.342 by allele). Moreover, the GMDR model showed that the interaction between GSTA1 rs3957357 and GPX3 rs736775 was associated significantly with SCZ risk, P=0.0107.Conclusion: Our results suggest that GSTA1 rs3957357 SNP has an effect on the risk of SCZ and the interaction between GSTA1 rs3957357and GPX3 rs736775 may affect the development of SCZ in Chinese Han population. However, these results should be validated by replication in different populations with large sample sizes.Keywords: oxidative stress, schizophrenia, glutathione peroxidase, glutathione S-transferase, gene polymorphismLiu CSong SZhang JLi XGao HDove Medical Pressarticleoxidative stressschizophreniaglutathione peroxidaseglutathione s-transferasegene polymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 113-118 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress schizophrenia glutathione peroxidase glutathione s-transferase gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	oxidative stress schizophrenia glutathione peroxidase glutathione s-transferase gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu C Song S Zhang J Li X Gao H Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
description	Chao Liu,1 Sijia Song,2 Junkai Zhang,1 Xiao Li,1 Huijie Gao1 1College of Pharmacy, Jining Medical University, Rizhao, Shandong, People’s Republic of China; 2Rizhao Mental Health Center, Rizhao, Shandong, People’s Republic of ChinaCorrespondence: Huijie GaoCollege of Pharmacy, Jining Medical University, 669 Xueyuan Road, Rizhao 276826, People’s Republic of ChinaTel +86 15954014646Email mianyigao@163.comPurpose: Several lines of evidence support the fact that the presence of oxidative stress plays an important role in the pathophysiological mechanisms of schizophrenia (SCZ). The glutathione peroxidases (GPXs) and glutathione S-transferases (GSTs) are the major antioxidant enzymes. Polymorphic variants of GPX and GST can affect the antioxidant activities of their encoded enzymes. This study explored the possible associations of the GSTA1 and GPX3 gene polymorphisms and schizophrenia in Chinese Han population.Methods: DNA from 648 healthy controls and 617 schizophrenic patients was genotyped for single-nucleotide polymorphisms (SNPs) rs3957357 in GSTA1 and rs736775 in GPX3 using a PCR-LDR genotyping assay. The χ2 test compared differences in genetic distributions between the two groups in a case–control study. The generalized multifactor dimensionality reduction (GMDR) was used to explore the interaction between the GSTA1 gene and the GPX3 gene on the risk of SCZ.Results: Significant differences in allelic and genotypic frequencies of GSTA1 rs3957357 were present between SCZ and control groups (GSTA1 rs3957357 χ2=6.172, P=0.046 by genotype, χ2=5.847, P=0.016, odds ratio=1.329, 95% confidence interval=1.055–1.674 by allele). No significant differences in allelic or genotypic frequencies of GPX3 rs736775 were detected between cases and controls (GPX3 rs736775: χ2=2.058, P=0.357 by genotype, χ2=1.853, P=0.173, odds ratio=1.131, 95% confidence interval=0.953–1.342 by allele). Moreover, the GMDR model showed that the interaction between GSTA1 rs3957357 and GPX3 rs736775 was associated significantly with SCZ risk, P=0.0107.Conclusion: Our results suggest that GSTA1 rs3957357 SNP has an effect on the risk of SCZ and the interaction between GSTA1 rs3957357and GPX3 rs736775 may affect the development of SCZ in Chinese Han population. However, these results should be validated by replication in different populations with large sample sizes.Keywords: oxidative stress, schizophrenia, glutathione peroxidase, glutathione S-transferase, gene polymorphism
format	article
author	Liu C Song S Zhang J Li X Gao H
author_facet	Liu C Song S Zhang J Li X Gao H
author_sort	Liu C
title	Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
title_short	Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
title_full	Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
title_fullStr	Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
title_full_unstemmed	Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
title_sort	effects of gsta1 and gpx3 polymorphisms on the risk of schizophrenia in chinese han population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0cb9a96c353d47f7bd32477495af1027
work_keys_str_mv	AT liuc effectsofgsta1andgpx3polymorphismsontheriskofschizophreniainchinesehanpopulation AT songs effectsofgsta1andgpx3polymorphismsontheriskofschizophreniainchinesehanpopulation AT zhangj effectsofgsta1andgpx3polymorphismsontheriskofschizophreniainchinesehanpopulation AT lix effectsofgsta1andgpx3polymorphismsontheriskofschizophreniainchinesehanpopulation AT gaoh effectsofgsta1andgpx3polymorphismsontheriskofschizophreniainchinesehanpopulation
_version_	1718398405106991104

Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population

Ejemplares similares