Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes

Abstract Hyperlipidemia is a risk factor for cardiovascular disease, and miR-21a-5p plays an important role in the occurrence and progression of hyperlipidemia. Here, we aimed to investigate the mechanism of aerobic exercise improved hyperlipidemia through enhancing miR-21a-5p expression. In this st...

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Autores principales:	Jinfeng Zhao, Yicun Song, Yu Zeng, Longchang Chen, Feng Yan, Anping Chen, Baoai Wu, Yaxin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cbae475f7934cb48305bfd34ff973fd
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spelling	oai:doaj.org-article:0cbae475f7934cb48305bfd34ff973fd2021-12-02T17:47:03ZImprovement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes10.1038/s41598-021-91583-82045-2322https://doaj.org/article/0cbae475f7934cb48305bfd34ff973fd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91583-8https://doaj.org/toc/2045-2322Abstract Hyperlipidemia is a risk factor for cardiovascular disease, and miR-21a-5p plays an important role in the occurrence and progression of hyperlipidemia. Here, we aimed to investigate the mechanism of aerobic exercise improved hyperlipidemia through enhancing miR-21a-5p expression. In this study, high-fat/high-cholesterol diet mice received 8 weeks of aerobic exercise intervention, then we collected plasma and liver samples, we found that there had a notable improvement in weight gain, blood lipid level, and liver steatosis in hyperlipidemia mice after 8 weeks of aerobic exercise intervention. Besides, aerobic exercise significantly up-regulated the expression of miR-21a-5p and provoked favorable changes in the expression of target genes. Knockdown of miR-21a-5p resulted in dysregulation of lipid metabolism and increased expression of FABP7, HMGCR, ACAT1, and OLR1. While aerobic exercise could alleviate miR-21a-5p knock-down induced lipid metabolism disorder. Taken together, these results demonstrated that aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1, and OLR1.Jinfeng ZhaoYicun SongYu ZengLongchang ChenFeng YanAnping ChenBaoai WuYaxin WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinfeng Zhao Yicun Song Yu Zeng Longchang Chen Feng Yan Anping Chen Baoai Wu Yaxin Wang Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
description	Abstract Hyperlipidemia is a risk factor for cardiovascular disease, and miR-21a-5p plays an important role in the occurrence and progression of hyperlipidemia. Here, we aimed to investigate the mechanism of aerobic exercise improved hyperlipidemia through enhancing miR-21a-5p expression. In this study, high-fat/high-cholesterol diet mice received 8 weeks of aerobic exercise intervention, then we collected plasma and liver samples, we found that there had a notable improvement in weight gain, blood lipid level, and liver steatosis in hyperlipidemia mice after 8 weeks of aerobic exercise intervention. Besides, aerobic exercise significantly up-regulated the expression of miR-21a-5p and provoked favorable changes in the expression of target genes. Knockdown of miR-21a-5p resulted in dysregulation of lipid metabolism and increased expression of FABP7, HMGCR, ACAT1, and OLR1. While aerobic exercise could alleviate miR-21a-5p knock-down induced lipid metabolism disorder. Taken together, these results demonstrated that aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1, and OLR1.
format	article
author	Jinfeng Zhao Yicun Song Yu Zeng Longchang Chen Feng Yan Anping Chen Baoai Wu Yaxin Wang
author_facet	Jinfeng Zhao Yicun Song Yu Zeng Longchang Chen Feng Yan Anping Chen Baoai Wu Yaxin Wang
author_sort	Jinfeng Zhao
title	Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
title_short	Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
title_full	Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
title_fullStr	Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
title_full_unstemmed	Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes
title_sort	improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of mir-21a-5p on its target genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0cbae475f7934cb48305bfd34ff973fd
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Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes

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