Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis

Abstract Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuo Zhang, Chenyu Pan, Xiangdong Lv, Wei Wu, Hao Chen, Wenqing Wu, Hailong Wu, Lei Zhang, Yun Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cbcd86d86b9475698a99f78b6a3c8f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0cbcd86d86b9475698a99f78b6a3c8f3
record_format	dspace
spelling	oai:doaj.org-article:0cbcd86d86b9475698a99f78b6a3c8f32021-12-02T12:32:45ZRepression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis10.1038/s41598-017-05359-02045-2322https://doaj.org/article/0cbcd86d86b9475698a99f78b6a3c8f32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05359-0https://doaj.org/toc/2045-2322Abstract Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.Shuo ZhangChenyu PanXiangdong LvWei WuHao ChenWenqing WuHailong WuLei ZhangYun ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuo Zhang Chenyu Pan Xiangdong Lv Wei Wu Hao Chen Wenqing Wu Hailong Wu Lei Zhang Yun Zhao Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
description	Abstract Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.
format	article
author	Shuo Zhang Chenyu Pan Xiangdong Lv Wei Wu Hao Chen Wenqing Wu Hailong Wu Lei Zhang Yun Zhao
author_facet	Shuo Zhang Chenyu Pan Xiangdong Lv Wei Wu Hao Chen Wenqing Wu Hailong Wu Lei Zhang Yun Zhao
author_sort	Shuo Zhang
title	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
title_short	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
title_full	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
title_fullStr	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
title_full_unstemmed	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
title_sort	repression of abd-b by polycomb is critical for cell identity maintenance in adult drosophila testis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0cbcd86d86b9475698a99f78b6a3c8f3
work_keys_str_mv	AT shuozhang repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT chenyupan repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT xiangdonglv repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT weiwu repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT haochen repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT wenqingwu repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT hailongwu repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT leizhang repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis AT yunzhao repressionofabdbbypolycombiscriticalforcellidentitymaintenanceinadultdrosophilatestis
_version_	1718393960351662080

Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis

Ejemplares similares