Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

<h4>Introduction</h4>Colorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed chromosomal instability (CIN) and excessively shortened telomeres. Up to 80% of CRC is microsatellite stable (MSS) and is historically considered to be chromosomally unstable (CIN+). Howe...

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Main Authors: Lisa A Boardman, Ruth A Johnson, Kimberly B Viker, Kari A Hafner, Robert B Jenkins, Douglas L Riegert-Johnson, Thomas C Smyrk, Kristin Litzelman, Songwon Seo, Ronald E Gangnon, Corinne D Engelman, David N Rider, Russell J Vanderboom, Stephen N Thibodeau, Gloria M Petersen, Halcyon G Skinner
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/0cbf7004f69043d4a6e8c2961198119c
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