DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates r...

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Autores principales:	Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cc0fcac27b44c6fbf79164cbd22e050
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spelling	oai:doaj.org-article:0cc0fcac27b44c6fbf79164cbd22e0502021-12-02T16:51:01ZDNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering10.1038/s41467-019-12640-52041-1723https://doaj.org/article/0cc0fcac27b44c6fbf79164cbd22e0502019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12640-5https://doaj.org/toc/2041-1723ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates reductive stress.Chiara MilaneseCíntia R. BombardieriSara SepeSander BarnhoornCésar Payán-GomézDonatella CarusoMatteo AudanoSilvia PedrettiWilbert P. VermeijRenata M. C. BrandtAkos GyenisMirjam M. WamelinkAnnelieke S. de WitRoel C. JanssensRené LeenAndré B. P. van KuilenburgNico MitroJan H. J. HoeijmakersPier G. MastroberardinoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Milanese Cíntia R. Bombardieri Sara Sepe Sander Barnhoorn César Payán-Goméz Donatella Caruso Matteo Audano Silvia Pedretti Wilbert P. Vermeij Renata M. C. Brandt Akos Gyenis Mirjam M. Wamelink Annelieke S. de Wit Roel C. Janssens René Leen André B. P. van Kuilenburg Nico Mitro Jan H. J. Hoeijmakers Pier G. Mastroberardino DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
description	ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates reductive stress.
format	article
author	Chiara Milanese Cíntia R. Bombardieri Sara Sepe Sander Barnhoorn César Payán-Goméz Donatella Caruso Matteo Audano Silvia Pedretti Wilbert P. Vermeij Renata M. C. Brandt Akos Gyenis Mirjam M. Wamelink Annelieke S. de Wit Roel C. Janssens René Leen André B. P. van Kuilenburg Nico Mitro Jan H. J. Hoeijmakers Pier G. Mastroberardino
author_facet	Chiara Milanese Cíntia R. Bombardieri Sara Sepe Sander Barnhoorn César Payán-Goméz Donatella Caruso Matteo Audano Silvia Pedretti Wilbert P. Vermeij Renata M. C. Brandt Akos Gyenis Mirjam M. Wamelink Annelieke S. de Wit Roel C. Janssens René Leen André B. P. van Kuilenburg Nico Mitro Jan H. J. Hoeijmakers Pier G. Mastroberardino
author_sort	Chiara Milanese
title	DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
title_short	DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
title_full	DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
title_fullStr	DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
title_full_unstemmed	DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
title_sort	dna damage and transcription stress cause atp-mediated redesign of metabolism and potentiation of anti-oxidant buffering
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0cc0fcac27b44c6fbf79164cbd22e050
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DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

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