Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens
Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.
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2018
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oai:doaj.org-article:0cc1ce5890644caa8d427f42892418e72021-12-02T14:41:17ZProteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens10.1038/s41467-018-07750-52041-1723https://doaj.org/article/0cc1ce5890644caa8d427f42892418e72018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07750-5https://doaj.org/toc/2041-1723Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.Sylvain NormandNadine WaldschmittAndreas NeerincxRuben Julio Martinez-TorresCamille ChauvinAurélie Couturier-MaillardOlivier BoulardLaetitia CobretFawaz AwadLudovic HuotAndre Ribeiro-RibeiroKatja LautzRichard RuezMyriam DelacreClovis BonduMartin GuilliamsCharlotte ScottAnthony SegalSerge AmselemDavid HotSonia KarabinaErwin BohnBernhard RyffelLionel F. PoulinThomas A. KuferMathias ChamaillardNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Sylvain Normand Nadine Waldschmitt Andreas Neerincx Ruben Julio Martinez-Torres Camille Chauvin Aurélie Couturier-Maillard Olivier Boulard Laetitia Cobret Fawaz Awad Ludovic Huot Andre Ribeiro-Ribeiro Katja Lautz Richard Ruez Myriam Delacre Clovis Bondu Martin Guilliams Charlotte Scott Anthony Segal Serge Amselem David Hot Sonia Karabina Erwin Bohn Bernhard Ryffel Lionel F. Poulin Thomas A. Kufer Mathias Chamaillard Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| description |
Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection. |
| format |
article |
| author |
Sylvain Normand Nadine Waldschmitt Andreas Neerincx Ruben Julio Martinez-Torres Camille Chauvin Aurélie Couturier-Maillard Olivier Boulard Laetitia Cobret Fawaz Awad Ludovic Huot Andre Ribeiro-Ribeiro Katja Lautz Richard Ruez Myriam Delacre Clovis Bondu Martin Guilliams Charlotte Scott Anthony Segal Serge Amselem David Hot Sonia Karabina Erwin Bohn Bernhard Ryffel Lionel F. Poulin Thomas A. Kufer Mathias Chamaillard |
| author_facet |
Sylvain Normand Nadine Waldschmitt Andreas Neerincx Ruben Julio Martinez-Torres Camille Chauvin Aurélie Couturier-Maillard Olivier Boulard Laetitia Cobret Fawaz Awad Ludovic Huot Andre Ribeiro-Ribeiro Katja Lautz Richard Ruez Myriam Delacre Clovis Bondu Martin Guilliams Charlotte Scott Anthony Segal Serge Amselem David Hot Sonia Karabina Erwin Bohn Bernhard Ryffel Lionel F. Poulin Thomas A. Kufer Mathias Chamaillard |
| author_sort |
Sylvain Normand |
| title |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| title_short |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| title_full |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| title_fullStr |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| title_full_unstemmed |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| title_sort |
proteasomal degradation of nod2 by nlrp12 in monocytes promotes bacterial tolerance and colonization by enteropathogens |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0cc1ce5890644caa8d427f42892418e7 |
| work_keys_str_mv |
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1718389913622151168 |