Detrimental relevance of Helicobacter pylori infection with sarcopenia

Abstract Background Helicobacter pylori (H. pylori), Gram negative microaerophilic bacteria, is a well-known pathogen of many gastrointestinal diseases. But several emerging evidences suggest it role in numerous other extra-gastric diseases. The current study investigates the relationship between H....

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Autores principales:	Shou-En Wu, Wei-Liang Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Helicobacter pylori Sarcopenia Muscle mass Eradication therapy Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/0cc20fe05ae740f585612b653cfb37c2
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spelling	oai:doaj.org-article:0cc20fe05ae740f585612b653cfb37c22021-11-21T12:14:28ZDetrimental relevance of Helicobacter pylori infection with sarcopenia10.1186/s13099-021-00464-y1757-4749https://doaj.org/article/0cc20fe05ae740f585612b653cfb37c22021-11-01T00:00:00Zhttps://doi.org/10.1186/s13099-021-00464-yhttps://doaj.org/toc/1757-4749Abstract Background Helicobacter pylori (H. pylori), Gram negative microaerophilic bacteria, is a well-known pathogen of many gastrointestinal diseases. But several emerging evidences suggest it role in numerous other extra-gastric diseases. The current study investigates the relationship between H. pylori infection and sarcopenia, a clinical condition characterized by the loss of mass and function of skeletal muscle. A total of 3453 eligible participants from the Third National Health and Nutrition Examination Survey (NHANES III), the United States, were enrolled. Based on the serum laboratory results, subjects were categorized into three groups: normal (without evidence of any H. pylori infection), anti-H. pylori IgG positive [H. pylori (+)], and concurrent anti-H. pylori IgG and anti-cytotoxin-associated gene A IgG positive [CagA (+)]. Sarcopenia was determined as having a skeletal muscle index (SMI) value that is more than 1 standard deviation away from the mean value of sex-specific, healthy young adults between 20 and 39 years old. Risk of sarcopenia and its components are compared between subgroups. Results Odds ratios (OR) for confirmed diagnosis of sarcopenia were higher in H. pylori (+) (OR = 2.052, 95% CI 1.697–2.481, p < 0.001) and CagA (+) (OR = 1.585, 95% CI 1.278–1.965, p < 0.001) groups. Moreover, negative beta regression coefficient of SMI were shown in H. pylori (+) (β: − 0.023, p < 0.001) and CagA (+) (β: − 0.017, p < 0.001). Sub-analyses which categorized participants by gender revealed that absolute value of beta regression coefficient for SMI were higher in female in H. pylori (+) subgroup (β: − 1.745 in male and − 2.942 in female, p were both < 0.001), and the CagA (+) subgroup (β: − 1.407 in male and − 2.159 in female, p were both < 0.001). Conclusions Positive serum H. pylori infectious markers including anti-H. pylori antibody and CagA seropositivity are correlated with sarcopenia and low muscle quantity. Therefore, H. pylori eradication therapy may bring benefits to sarcopenia patients with concurrent active H. pylori infection.Shou-En WuWei-Liang ChenBMCarticleHelicobacter pyloriSarcopeniaMuscle massEradication therapyDiseases of the digestive system. GastroenterologyRC799-869ENGut Pathogens, Vol 13, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Helicobacter pylori Sarcopenia Muscle mass Eradication therapy Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Helicobacter pylori Sarcopenia Muscle mass Eradication therapy Diseases of the digestive system. Gastroenterology RC799-869 Shou-En Wu Wei-Liang Chen Detrimental relevance of Helicobacter pylori infection with sarcopenia
description	Abstract Background Helicobacter pylori (H. pylori), Gram negative microaerophilic bacteria, is a well-known pathogen of many gastrointestinal diseases. But several emerging evidences suggest it role in numerous other extra-gastric diseases. The current study investigates the relationship between H. pylori infection and sarcopenia, a clinical condition characterized by the loss of mass and function of skeletal muscle. A total of 3453 eligible participants from the Third National Health and Nutrition Examination Survey (NHANES III), the United States, were enrolled. Based on the serum laboratory results, subjects were categorized into three groups: normal (without evidence of any H. pylori infection), anti-H. pylori IgG positive [H. pylori (+)], and concurrent anti-H. pylori IgG and anti-cytotoxin-associated gene A IgG positive [CagA (+)]. Sarcopenia was determined as having a skeletal muscle index (SMI) value that is more than 1 standard deviation away from the mean value of sex-specific, healthy young adults between 20 and 39 years old. Risk of sarcopenia and its components are compared between subgroups. Results Odds ratios (OR) for confirmed diagnosis of sarcopenia were higher in H. pylori (+) (OR = 2.052, 95% CI 1.697–2.481, p < 0.001) and CagA (+) (OR = 1.585, 95% CI 1.278–1.965, p < 0.001) groups. Moreover, negative beta regression coefficient of SMI were shown in H. pylori (+) (β: − 0.023, p < 0.001) and CagA (+) (β: − 0.017, p < 0.001). Sub-analyses which categorized participants by gender revealed that absolute value of beta regression coefficient for SMI were higher in female in H. pylori (+) subgroup (β: − 1.745 in male and − 2.942 in female, p were both < 0.001), and the CagA (+) subgroup (β: − 1.407 in male and − 2.159 in female, p were both < 0.001). Conclusions Positive serum H. pylori infectious markers including anti-H. pylori antibody and CagA seropositivity are correlated with sarcopenia and low muscle quantity. Therefore, H. pylori eradication therapy may bring benefits to sarcopenia patients with concurrent active H. pylori infection.
format	article
author	Shou-En Wu Wei-Liang Chen
author_facet	Shou-En Wu Wei-Liang Chen
author_sort	Shou-En Wu
title	Detrimental relevance of Helicobacter pylori infection with sarcopenia
title_short	Detrimental relevance of Helicobacter pylori infection with sarcopenia
title_full	Detrimental relevance of Helicobacter pylori infection with sarcopenia
title_fullStr	Detrimental relevance of Helicobacter pylori infection with sarcopenia
title_full_unstemmed	Detrimental relevance of Helicobacter pylori infection with sarcopenia
title_sort	detrimental relevance of helicobacter pylori infection with sarcopenia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0cc20fe05ae740f585612b653cfb37c2
work_keys_str_mv	AT shouenwu detrimentalrelevanceofhelicobacterpyloriinfectionwithsarcopenia AT weiliangchen detrimentalrelevanceofhelicobacterpyloriinfectionwithsarcopenia
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Detrimental relevance of Helicobacter pylori infection with sarcopenia

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