Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protein import with the translocase subunit Timm50.

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Detalles Bibliográficos
Autores principales: Natalie M. Niemi, Gary M. Wilson, Katherine A. Overmyer, F.-Nora Vögtle, Lisa Myketin, Danielle C. Lohman, Kathryn L. Schueler, Alan D. Attie, Chris Meisinger, Joshua J. Coon, David J. Pagliarini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0cc3120d036a46b9807f1cae4a084aeb
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Descripción
Sumario:The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protein import with the translocase subunit Timm50.