Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography

Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography

Panitha Jindahra,1 Nitchanan Hengsiri,1 Pirada Witoonpanich,1 Anuchit Poonyathalang,2 Teeratorn Pulkes,1 Supoch Tunlayadechanont,1 Kunlawat Thadanipon,3 Kavin Vanikieti2 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jindahra P, Hengsiri N, Witoonpanich P, Poonyathalang A, Pulkes T, Tunlayadechanont S, Thadanipon K, Vanikieti K
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
alzheimer’s disease
optical coherence tomography
retinal nerve fiber layer
ganglion cell layer
dementia
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/0cc4b833ce484f16a5c0f930b57899f9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0cc4b833ce484f16a5c0f930b57899f9
record_format dspace
spelling oai:doaj.org-article:0cc4b833ce484f16a5c0f930b57899f92021-12-02T11:15:29ZEvaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography1177-5483https://doaj.org/article/0cc4b833ce484f16a5c0f930b57899f92020-10-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-retinal-nerve-fiber-layer-and-ganglion-cell-layer-thickn-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Panitha Jindahra,1 Nitchanan Hengsiri,1 Pirada Witoonpanich,1 Anuchit Poonyathalang,2 Teeratorn Pulkes,1 Supoch Tunlayadechanont,1 Kunlawat Thadanipon,3 Kavin Vanikieti2 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Department of Ophthalmology, Faculty of Medicine Ramathibodi HospitalMahidol University, 270 Rama VI Road, Bangkok 10400, ThailandTel +662 201 1526Fax +662 201 2729Email Vanikieti.kavin@gmail.comObjective: To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer’s disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).Material and Methods: This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best-corrected visual acuity, hypertension, diabetes and dyslipidemia.Results: The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 μm, respectively, adjusted P=0.014). The superior quadrant was thinner in the AD group (adjusted P=0.033). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 μm) was significantly thinner than that in the controls (76.42 μm) (adjusted P=0.014). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r=− 0.338, P=0.010 and r=− 0.346, P=0.008, respectively).Conclusion: The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.Keywords: Alzheimer’s disease, optical coherence tomography, retinal nerve fiber layer, ganglion cell layer, dementiaJindahra PHengsiri NWitoonpanich PPoonyathalang APulkes TTunlayadechanont SThadanipon KVanikieti KDove Medical Pressarticlealzheimer’s diseaseoptical coherence tomographyretinal nerve fiber layerganglion cell layerdementiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2995-3000 (2020)
institution DOAJ
collection DOAJ
language EN
topic alzheimer’s disease
optical coherence tomography
retinal nerve fiber layer
ganglion cell layer
dementia
Ophthalmology
RE1-994
spellingShingle alzheimer’s disease
optical coherence tomography
retinal nerve fiber layer
ganglion cell layer
dementia
Ophthalmology
RE1-994
Jindahra P
Hengsiri N
Witoonpanich P
Poonyathalang A
Pulkes T
Tunlayadechanont S
Thadanipon K
Vanikieti K
Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
description Panitha Jindahra,1 Nitchanan Hengsiri,1 Pirada Witoonpanich,1 Anuchit Poonyathalang,2 Teeratorn Pulkes,1 Supoch Tunlayadechanont,1 Kunlawat Thadanipon,3 Kavin Vanikieti2 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Department of Ophthalmology, Faculty of Medicine Ramathibodi HospitalMahidol University, 270 Rama VI Road, Bangkok 10400, ThailandTel +662 201 1526Fax +662 201 2729Email Vanikieti.kavin@gmail.comObjective: To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer’s disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).Material and Methods: This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best-corrected visual acuity, hypertension, diabetes and dyslipidemia.Results: The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 μm, respectively, adjusted P=0.014). The superior quadrant was thinner in the AD group (adjusted P=0.033). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 μm) was significantly thinner than that in the controls (76.42 μm) (adjusted P=0.014). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r=− 0.338, P=0.010 and r=− 0.346, P=0.008, respectively).Conclusion: The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.Keywords: Alzheimer’s disease, optical coherence tomography, retinal nerve fiber layer, ganglion cell layer, dementia
format article
author Jindahra P
Hengsiri N
Witoonpanich P
Poonyathalang A
Pulkes T
Tunlayadechanont S
Thadanipon K
Vanikieti K
author_facet Jindahra P
Hengsiri N
Witoonpanich P
Poonyathalang A
Pulkes T
Tunlayadechanont S
Thadanipon K
Vanikieti K
author_sort Jindahra P
title Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
title_short Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
title_full Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
title_fullStr Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
title_full_unstemmed Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Layer Thickness in Alzheimer’s Disease Using Optical Coherence Tomography
title_sort evaluation of retinal nerve fiber layer and ganglion cell layer thickness in alzheimer’s disease using optical coherence tomography
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/0cc4b833ce484f16a5c0f930b57899f9
work_keys_str_mv AT jindahrap evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT hengsirin evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT witoonpanichp evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT poonyathalanga evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT pulkest evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT tunlayadechanonts evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT thadaniponk evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
AT vanikietik evaluationofretinalnervefiberlayerandganglioncelllayerthicknessinalzheimerrsquosdiseaseusingopticalcoherencetomography
_version_ 1718396036999806976

Ejemplares similares