Structure and assembly of scalable porous protein cages

Self-assembling proteins that form capsid-like structures act as molecular containers for diverse cargoes. Here, the authors solve the cryo-EM structures of lumazine synthase shells, and show that supercharged mutants form expanded assemblies, indicating that electrostatics can be exploited to engin...

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Autores principales:	Eita Sasaki, Daniel Böhringer, Michiel van de Waterbeemd, Marc Leibundgut, Reinhard Zschoche, Albert J. R. Heck, Nenad Ban, Donald Hilvert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cc4c87845844521b4c3d130450e24dc
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spelling	oai:doaj.org-article:0cc4c87845844521b4c3d130450e24dc2021-12-02T17:06:16ZStructure and assembly of scalable porous protein cages10.1038/ncomms146632041-1723https://doaj.org/article/0cc4c87845844521b4c3d130450e24dc2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14663https://doaj.org/toc/2041-1723Self-assembling proteins that form capsid-like structures act as molecular containers for diverse cargoes. Here, the authors solve the cryo-EM structures of lumazine synthase shells, and show that supercharged mutants form expanded assemblies, indicating that electrostatics can be exploited to engineer cage architecture.Eita SasakiDaniel BöhringerMichiel van de WaterbeemdMarc LeibundgutReinhard ZschocheAlbert J. R. HeckNenad BanDonald HilvertNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eita Sasaki Daniel Böhringer Michiel van de Waterbeemd Marc Leibundgut Reinhard Zschoche Albert J. R. Heck Nenad Ban Donald Hilvert Structure and assembly of scalable porous protein cages
description	Self-assembling proteins that form capsid-like structures act as molecular containers for diverse cargoes. Here, the authors solve the cryo-EM structures of lumazine synthase shells, and show that supercharged mutants form expanded assemblies, indicating that electrostatics can be exploited to engineer cage architecture.
format	article
author	Eita Sasaki Daniel Böhringer Michiel van de Waterbeemd Marc Leibundgut Reinhard Zschoche Albert J. R. Heck Nenad Ban Donald Hilvert
author_facet	Eita Sasaki Daniel Böhringer Michiel van de Waterbeemd Marc Leibundgut Reinhard Zschoche Albert J. R. Heck Nenad Ban Donald Hilvert
author_sort	Eita Sasaki
title	Structure and assembly of scalable porous protein cages
title_short	Structure and assembly of scalable porous protein cages
title_full	Structure and assembly of scalable porous protein cages
title_fullStr	Structure and assembly of scalable porous protein cages
title_full_unstemmed	Structure and assembly of scalable porous protein cages
title_sort	structure and assembly of scalable porous protein cages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0cc4c87845844521b4c3d130450e24dc
work_keys_str_mv	AT eitasasaki structureandassemblyofscalableporousproteincages AT danielbohringer structureandassemblyofscalableporousproteincages AT michielvandewaterbeemd structureandassemblyofscalableporousproteincages AT marcleibundgut structureandassemblyofscalableporousproteincages AT reinhardzschoche structureandassemblyofscalableporousproteincages AT albertjrheck structureandassemblyofscalableporousproteincages AT nenadban structureandassemblyofscalableporousproteincages AT donaldhilvert structureandassemblyofscalableporousproteincages
_version_	1718381657282576384

Structure and assembly of scalable porous protein cages

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