Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.

<h4>Background</h4>Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown.<h4>Methodology/principa...

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Autores principales:	Xiu-Ming Wu, Cheng-Ping Hu, Xiao-Zhao Li, Ye-Qiang Zou, Jun-Tao Zou, Yuan-Yuan Li, Jun-Tao Feng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cc4f58c0799437bbe355536918706fb
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spelling	oai:doaj.org-article:0cc4f58c0799437bbe355536918706fb2021-11-18T06:52:59ZAsthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.1932-620310.1371/journal.pone.0020337https://doaj.org/article/0cc4f58c0799437bbe355536918706fb2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21647384/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown.<h4>Methodology/principal findings</h4>This study aims to explore the influence of maternal asthma during pregnancy on the development and function of adrenal medulla in offspring from postnatal day 3 (P3) to postnatal day 60 (P60). Asthmatic pregnant rats (AP), nerve growth factor (NGF)-treated pregnant rats (NP) and NGF antibody-treated pregnant rats (ANP) were sensitized and challenged with ovalbumin (OVA); NP and ANP were treated with NGF and NGF antibody respectively. Offspring rats from the maternal group were divided into four groups: offspring from control pregnant rats (OCP), offspring from AP (OAP), offspring from NP (ONP), and offspring from ANP (OANP). The expressions of phenylethanolamine N-methyltransferase (PNMT) protein in adrenal medulla were analyzed. The concentrations of epinephrine (EPI), corticosterone and NGF in serum were measured. Adrenal medulla chromaffin cells (AMCC) were prone to differentiate into sympathetic nerve cells in OAP and ONP. Both EPI and PNMT were decreased in OAP from P3 to P14, and then reached normal level gradually from P30 to P60, which were lower from birth to adulthood in ONP. Corticosterone concentration increased significantly in OAP and ONP.<h4>Conclusion/significance</h4>Asthma pregnancy may promote AMCC to differentiate into sympathetic neurons in offspring rats and inhibit the synthesis of EPI, resulting in dysfunction of bronchial relaxation.Xiu-Ming WuCheng-Ping HuXiao-Zhao LiYe-Qiang ZouJun-Tao ZouYuan-Yuan LiJun-Tao FengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20337 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiu-Ming Wu Cheng-Ping Hu Xiao-Zhao Li Ye-Qiang Zou Jun-Tao Zou Yuan-Yuan Li Jun-Tao Feng Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
description	<h4>Background</h4>Adrenal neuroendocrine plays an important role in asthma. The activity of the sympathoadrenal system could be altered by early life events. The effects of maternal asthma during pregnancy on the adrenal medulla of offspring remain unknown.<h4>Methodology/principal findings</h4>This study aims to explore the influence of maternal asthma during pregnancy on the development and function of adrenal medulla in offspring from postnatal day 3 (P3) to postnatal day 60 (P60). Asthmatic pregnant rats (AP), nerve growth factor (NGF)-treated pregnant rats (NP) and NGF antibody-treated pregnant rats (ANP) were sensitized and challenged with ovalbumin (OVA); NP and ANP were treated with NGF and NGF antibody respectively. Offspring rats from the maternal group were divided into four groups: offspring from control pregnant rats (OCP), offspring from AP (OAP), offspring from NP (ONP), and offspring from ANP (OANP). The expressions of phenylethanolamine N-methyltransferase (PNMT) protein in adrenal medulla were analyzed. The concentrations of epinephrine (EPI), corticosterone and NGF in serum were measured. Adrenal medulla chromaffin cells (AMCC) were prone to differentiate into sympathetic nerve cells in OAP and ONP. Both EPI and PNMT were decreased in OAP from P3 to P14, and then reached normal level gradually from P30 to P60, which were lower from birth to adulthood in ONP. Corticosterone concentration increased significantly in OAP and ONP.<h4>Conclusion/significance</h4>Asthma pregnancy may promote AMCC to differentiate into sympathetic neurons in offspring rats and inhibit the synthesis of EPI, resulting in dysfunction of bronchial relaxation.
format	article
author	Xiu-Ming Wu Cheng-Ping Hu Xiao-Zhao Li Ye-Qiang Zou Jun-Tao Zou Yuan-Yuan Li Jun-Tao Feng
author_facet	Xiu-Ming Wu Cheng-Ping Hu Xiao-Zhao Li Ye-Qiang Zou Jun-Tao Zou Yuan-Yuan Li Jun-Tao Feng
author_sort	Xiu-Ming Wu
title	Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
title_short	Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
title_full	Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
title_fullStr	Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
title_full_unstemmed	Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
title_sort	asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0cc4f58c0799437bbe355536918706fb
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Asthma pregnancy alters postnatal development of chromaffin cells in the rat adrenal medulla.

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