Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genes

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Autores principales:	Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, Carla F. Bento, Kristian Franze, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a7
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spelling	oai:doaj.org-article:0cc58f26136b45e7a5358ff2da4265a72021-12-02T17:32:34ZContact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis10.1038/s41467-018-05388-x2041-1723https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05388-xhttps://doaj.org/toc/2041-1723At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genesMariana PavelMaurizio RennaSo Jung ParkFiona M. MenziesThomas RickettsJens FüllgrabeAvraham AshkenaziRebecca A. FrakeAlejandro Carnicer LombarteCarla F. BentoKristian FranzeDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariana Pavel Maurizio Renna So Jung Park Fiona M. Menzies Thomas Ricketts Jens Füllgrabe Avraham Ashkenazi Rebecca A. Frake Alejandro Carnicer Lombarte Carla F. Bento Kristian Franze David C. Rubinsztein Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
description	At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genes
format	article
author	Mariana Pavel Maurizio Renna So Jung Park Fiona M. Menzies Thomas Ricketts Jens Füllgrabe Avraham Ashkenazi Rebecca A. Frake Alejandro Carnicer Lombarte Carla F. Bento Kristian Franze David C. Rubinsztein
author_facet	Mariana Pavel Maurizio Renna So Jung Park Fiona M. Menzies Thomas Ricketts Jens Füllgrabe Avraham Ashkenazi Rebecca A. Frake Alejandro Carnicer Lombarte Carla F. Bento Kristian Franze David C. Rubinsztein
author_sort	Mariana Pavel
title	Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
title_short	Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
title_full	Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
title_fullStr	Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
title_full_unstemmed	Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
title_sort	contact inhibition controls cell survival and proliferation via yap/taz-autophagy axis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a7
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Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

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