CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA

Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”....

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Autores principales:	I. V. Kozlova, T. V. Demina, S. E. Tkachev, E. K. Doroshchenko, O. V. Lisak, M. M. Verkhozina, L. S. Karan, Yu. P. Dzhioev, A. I. Paramonov, O. V. Suntsova, Yu. S. Savinova, O. O. Chernoivanova, D. Ruzek, N. V. Tikunova, V. I. Zlobin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	tick-born encephalitis virus (tbev) genotype subtype Science Q
Acceso en línea:	https://doaj.org/article/0cc90dba0bc9402bb1b2681799ca13fb
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spelling	oai:doaj.org-article:0cc90dba0bc9402bb1b2681799ca13fb2021-11-23T06:14:40ZCHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA2541-94202587-959610.29413/ABS.2018-3.4.9https://doaj.org/article/0cc90dba0bc9402bb1b2681799ca13fb2018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/650https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the “group 886” strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV “886” group.Materials and methods. The genetic structure of “group 886” strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that “group 886” strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the “group 886” strains were considered.Conclusion. The presented data testify to the validity of the “886 group” isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name “Baikal genotype/subtype”.I. V. KozlovaT. V. DeminaS. E. TkachevE. K. DoroshchenkoO. V. LisakM. M. VerkhozinaL. S. KaranYu. P. DzhioevA. I. ParamonovO. V. SuntsovaYu. S. SavinovaO. O. ChernoivanovaD. RuzekN. V. TikunovaV. I. ZlobinScientific Сentre for Family Health and Human Reproduction Problemsarticletick-born encephalitis virus (tbev)genotypesubtypeScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 53-60 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-born encephalitis virus (tbev) genotype subtype Science Q
spellingShingle	tick-born encephalitis virus (tbev) genotype subtype Science Q I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
description	Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the “group 886” strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV “886” group.Materials and methods. The genetic structure of “group 886” strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that “group 886” strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the “group 886” strains were considered.Conclusion. The presented data testify to the validity of the “886 group” isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name “Baikal genotype/subtype”.
format	article
author	I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin
author_facet	I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin
author_sort	I. V. Kozlova
title	CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
title_short	CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
title_full	CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
title_fullStr	CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
title_full_unstemmed	CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
title_sort	characteristics of the baikal subtype of tick-borne encephalitis virus circulating in eastern siberia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/0cc90dba0bc9402bb1b2681799ca13fb
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CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA

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