Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis

Jørn Ditzel, Hans-Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: The acute effects of intracellular phosphate depletion and hypophosphatemia on organs and tissues in an...

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Autores principales:	Lervang H, Ditzel J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	diabetes mellitus inorganic phosphate diabetic ketoacidosis high energy phosphates hypoxia fructose 1 6-diphosphate Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0cc91db8b2b246be86be3237ab93867b
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spelling	oai:doaj.org-article:0cc91db8b2b246be86be3237ab93867b2021-12-02T03:19:13ZDisturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis1178-7007https://doaj.org/article/0cc91db8b2b246be86be3237ab93867b2010-09-01T00:00:00Zhttps://www.dovepress.com/disturbance-of-inorganic-phosphate-metabolism-in-diabetes-mellitus-cli-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jørn Ditzel, Hans-Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: The acute effects of intracellular phosphate depletion and hypophosphatemia on organs and tissues in and during recovery from diabetic ketoacidosis (DKA) have been reviewed. When insufficient phosphate and/or oxygen are available for high energy phosphate synthesis, cell homeostasis cannot be maintained and cell integrity may be impaired. The clinical consequences are recognized as occasional cause of morbidity and mortality. Although phosphate repletion has not been routinely recommended in the treatment of DKA, physicians should be aware of these clinical conditions and phosphate repletion in such situations should be considered.Keywords: high energy phosphates, hypoxia, fructose 1,6-diphosphateLervang HDitzel JDove Medical Pressarticlediabetes mellitusinorganic phosphatediabetic ketoacidosishigh energy phosphateshypoxiafructose 16-diphosphateSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 319-324 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus inorganic phosphate diabetic ketoacidosis high energy phosphates hypoxia fructose 1 6-diphosphate Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus inorganic phosphate diabetic ketoacidosis high energy phosphates hypoxia fructose 1 6-diphosphate Specialties of internal medicine RC581-951 Lervang H Ditzel J Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
description	Jørn Ditzel, Hans-Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: The acute effects of intracellular phosphate depletion and hypophosphatemia on organs and tissues in and during recovery from diabetic ketoacidosis (DKA) have been reviewed. When insufficient phosphate and/or oxygen are available for high energy phosphate synthesis, cell homeostasis cannot be maintained and cell integrity may be impaired. The clinical consequences are recognized as occasional cause of morbidity and mortality. Although phosphate repletion has not been routinely recommended in the treatment of DKA, physicians should be aware of these clinical conditions and phosphate repletion in such situations should be considered.Keywords: high energy phosphates, hypoxia, fructose 1,6-diphosphate
format	article
author	Lervang H Ditzel J
author_facet	Lervang H Ditzel J
author_sort	Lervang H
title	Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
title_short	Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
title_full	Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
title_fullStr	Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
title_full_unstemmed	Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
title_sort	disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0cc91db8b2b246be86be3237ab93867b
work_keys_str_mv	AT lervangh disturbanceofinorganicphosphatemetabolismindiabetesmellitusclinicalmanifestationsofphosphorusdepletionsyndromeduringrecoveryfromdiabeticketoacidosis AT ditzelj disturbanceofinorganicphosphatemetabolismindiabetesmellitusclinicalmanifestationsofphosphorusdepletionsyndromeduringrecoveryfromdiabeticketoacidosis
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Disturbance of inorganic phosphate metabolism in diabetes mellitus: clinical manifestations of phosphorus-depletion syndrome during recovery from diabetic ketoacidosis

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