TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah Moyon, Rebecca Frawley, Damien Marechal, Dennis Huang, Katy L. H. Marshall-Phelps, Linde Kegel, Sunniva M. K. Bøstrand, Boguslawa Sadowski, Yong-Hui Jiang, David A. Lyons, Wiebke Möbius, Patrizia Casaccia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b7567
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0cc9b5962f0a40eabbf4462ab04b7567
record_format	dspace
spelling	oai:doaj.org-article:0cc9b5962f0a40eabbf4462ab04b75672021-12-02T17:34:34ZTET1-mediated DNA hydroxymethylation regulates adult remyelination in mice10.1038/s41467-021-23735-32041-1723https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b75672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23735-3https://doaj.org/toc/2041-1723Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.Sarah MoyonRebecca FrawleyDamien MarechalDennis HuangKaty L. H. Marshall-PhelpsLinde KegelSunniva M. K. BøstrandBoguslawa SadowskiYong-Hui JiangDavid A. LyonsWiebke MöbiusPatrizia CasacciaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Moyon Rebecca Frawley Damien Marechal Dennis Huang Katy L. H. Marshall-Phelps Linde Kegel Sunniva M. K. Bøstrand Boguslawa Sadowski Yong-Hui Jiang David A. Lyons Wiebke Möbius Patrizia Casaccia TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
description	Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.
format	article
author	Sarah Moyon Rebecca Frawley Damien Marechal Dennis Huang Katy L. H. Marshall-Phelps Linde Kegel Sunniva M. K. Bøstrand Boguslawa Sadowski Yong-Hui Jiang David A. Lyons Wiebke Möbius Patrizia Casaccia
author_facet	Sarah Moyon Rebecca Frawley Damien Marechal Dennis Huang Katy L. H. Marshall-Phelps Linde Kegel Sunniva M. K. Bøstrand Boguslawa Sadowski Yong-Hui Jiang David A. Lyons Wiebke Möbius Patrizia Casaccia
author_sort	Sarah Moyon
title	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
title_short	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
title_full	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
title_fullStr	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
title_full_unstemmed	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
title_sort	tet1-mediated dna hydroxymethylation regulates adult remyelination in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b7567
work_keys_str_mv	AT sarahmoyon tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT rebeccafrawley tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT damienmarechal tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT dennishuang tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT katylhmarshallphelps tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT lindekegel tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT sunnivamkbøstrand tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT boguslawasadowski tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT yonghuijiang tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT davidalyons tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT wiebkemobius tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice AT patriziacasaccia tet1mediateddnahydroxymethylationregulatesadultremyelinationinmice
_version_	1718379922199674880

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

Ejemplares similares