Bacillus subtilis utilizes the DNA damage response to manage multicellular development

Biofilm disruption: A bacterial escape plan Exposure to chemicals that damage DNA makes Bacillus subtilis bacteria turn off genes that maintain the biofilm state, releasing some bacteria. This mechanism to free cells from a biofilm is surprising, as biofilms holding bacteria together are generally c...

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Autores principales:	Kevin Gozzi, Carly Ching, Srinand Paruthiyil, Yinjuan Zhao, Veronica Godoy-Carter, Yunrong Chai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/0ccebd7b459246259552ffa3bfa5d924
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spelling	oai:doaj.org-article:0ccebd7b459246259552ffa3bfa5d9242021-12-02T11:42:16ZBacillus subtilis utilizes the DNA damage response to manage multicellular development10.1038/s41522-017-0016-32055-5008https://doaj.org/article/0ccebd7b459246259552ffa3bfa5d9242017-03-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0016-3https://doaj.org/toc/2055-5008Biofilm disruption: A bacterial escape plan Exposure to chemicals that damage DNA makes Bacillus subtilis bacteria turn off genes that maintain the biofilm state, releasing some bacteria. This mechanism to free cells from a biofilm is surprising, as biofilms holding bacteria together are generally considered to form as a protective mechanism for the bacteria. Yunrong Chai and colleagues at Northeastern University in Boston, USA, detected the surprising behavior in biofilms exposed to superoxide—a chemical species that damages DNA. They suggest that when the potential for damage to bacterial DNA reaches a threshold it signals that the environment is not suitable for cells to remain in the entrapped biofilm form, triggering disruption of the biofilm as a survival strategy. This response to DNA damage may be relevant to clinical conditions as biofilms are involved in many infectious diseases.Kevin GozziCarly ChingSrinand ParuthiyilYinjuan ZhaoVeronica Godoy-CarterYunrong ChaiNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Kevin Gozzi Carly Ching Srinand Paruthiyil Yinjuan Zhao Veronica Godoy-Carter Yunrong Chai Bacillus subtilis utilizes the DNA damage response to manage multicellular development
description	Biofilm disruption: A bacterial escape plan Exposure to chemicals that damage DNA makes Bacillus subtilis bacteria turn off genes that maintain the biofilm state, releasing some bacteria. This mechanism to free cells from a biofilm is surprising, as biofilms holding bacteria together are generally considered to form as a protective mechanism for the bacteria. Yunrong Chai and colleagues at Northeastern University in Boston, USA, detected the surprising behavior in biofilms exposed to superoxide—a chemical species that damages DNA. They suggest that when the potential for damage to bacterial DNA reaches a threshold it signals that the environment is not suitable for cells to remain in the entrapped biofilm form, triggering disruption of the biofilm as a survival strategy. This response to DNA damage may be relevant to clinical conditions as biofilms are involved in many infectious diseases.
format	article
author	Kevin Gozzi Carly Ching Srinand Paruthiyil Yinjuan Zhao Veronica Godoy-Carter Yunrong Chai
author_facet	Kevin Gozzi Carly Ching Srinand Paruthiyil Yinjuan Zhao Veronica Godoy-Carter Yunrong Chai
author_sort	Kevin Gozzi
title	Bacillus subtilis utilizes the DNA damage response to manage multicellular development
title_short	Bacillus subtilis utilizes the DNA damage response to manage multicellular development
title_full	Bacillus subtilis utilizes the DNA damage response to manage multicellular development
title_fullStr	Bacillus subtilis utilizes the DNA damage response to manage multicellular development
title_full_unstemmed	Bacillus subtilis utilizes the DNA damage response to manage multicellular development
title_sort	bacillus subtilis utilizes the dna damage response to manage multicellular development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ccebd7b459246259552ffa3bfa5d924
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Bacillus subtilis utilizes the DNA damage response to manage multicellular development

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