Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

Blood–brain barrier dysfunction occurs in ageing and in neurodegenerative diseases. Here, the authors use scRNA-seq to identify transcriptomic changes in endothelial cell subtypes in the aged mouse brain, some of which may generalize to human and can be reversed by treatment with a GLP-1R agonist.

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Autores principales:	Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, Hei-Ming Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C. T. Mok, Ho Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cd6b88e4d0b4038b2b9807cac7e8608
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spelling	oai:doaj.org-article:0cd6b88e4d0b4038b2b9807cac7e86082021-12-02T16:38:27ZPharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain10.1038/s41467-020-18249-32041-1723https://doaj.org/article/0cd6b88e4d0b4038b2b9807cac7e86082020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18249-3https://doaj.org/toc/2041-1723Blood–brain barrier dysfunction occurs in ageing and in neurodegenerative diseases. Here, the authors use scRNA-seq to identify transcriptomic changes in endothelial cell subtypes in the aged mouse brain, some of which may generalize to human and can be reversed by treatment with a GLP-1R agonist.Lei ZhaoZhongqi LiJoaquim S. L. VongXinyi ChenHei-Ming LaiLeo Y. C. YanJunzhe HuangSamuel K. H. SyXiaoyu TianYu HuangHo Yin Edwin ChanHon-Cheong SoWai-Lung NgYamei TangWei-Jye LinVincent C. T. MokHo KoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Zhao Zhongqi Li Joaquim S. L. Vong Xinyi Chen Hei-Ming Lai Leo Y. C. Yan Junzhe Huang Samuel K. H. Sy Xiaoyu Tian Yu Huang Ho Yin Edwin Chan Hon-Cheong So Wai-Lung Ng Yamei Tang Wei-Jye Lin Vincent C. T. Mok Ho Ko Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
description	Blood–brain barrier dysfunction occurs in ageing and in neurodegenerative diseases. Here, the authors use scRNA-seq to identify transcriptomic changes in endothelial cell subtypes in the aged mouse brain, some of which may generalize to human and can be reversed by treatment with a GLP-1R agonist.
format	article
author	Lei Zhao Zhongqi Li Joaquim S. L. Vong Xinyi Chen Hei-Ming Lai Leo Y. C. Yan Junzhe Huang Samuel K. H. Sy Xiaoyu Tian Yu Huang Ho Yin Edwin Chan Hon-Cheong So Wai-Lung Ng Yamei Tang Wei-Jye Lin Vincent C. T. Mok Ho Ko
author_facet	Lei Zhao Zhongqi Li Joaquim S. L. Vong Xinyi Chen Hei-Ming Lai Leo Y. C. Yan Junzhe Huang Samuel K. H. Sy Xiaoyu Tian Yu Huang Ho Yin Edwin Chan Hon-Cheong So Wai-Lung Ng Yamei Tang Wei-Jye Lin Vincent C. T. Mok Ho Ko
author_sort	Lei Zhao
title	Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
title_short	Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
title_full	Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
title_fullStr	Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
title_full_unstemmed	Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
title_sort	pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0cd6b88e4d0b4038b2b9807cac7e8608
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Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

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