Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin

Brassinin derived from Chinese cabbage has been reported to act as an anti-cancer agent on prostate, liver, and colon cancer cells. However, its mechanism and impact are largely unknown in colon cancer cells. Here, we first published a report that Brassinin induces apoptosis and inhibits the surviva...

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Autores principales:	Woon Yi Park, Ji Eon Park, Ji Hoon Jung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Brassinin p53 apoptosis doxorubicin colon cancer cell Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0cdb50ba3ba141e1aa2be3bb7fd352a8
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spelling	oai:doaj.org-article:0cdb50ba3ba141e1aa2be3bb7fd352a82021-11-11T15:07:03ZApoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin10.3390/app1121100362076-3417https://doaj.org/article/0cdb50ba3ba141e1aa2be3bb7fd352a82021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10036https://doaj.org/toc/2076-3417Brassinin derived from Chinese cabbage has been reported to act as an anti-cancer agent on prostate, liver, and colon cancer cells. However, its mechanism and impact are largely unknown in colon cancer cells. Here, we first published a report that Brassinin induces apoptosis and inhibits the survival of colon cancer cells by activating p53. We found that Brassinin induces p53 and p21 dose- and time-dependent manner in wild type of p53 colon cancer cells. Interestingly, Brassinin induces apoptosis in wild-type of p53 cancer cells, but not in null-type of p53 cancer cells dose dependently. Additionally, Brassinin induces apoptosis through L5. Furthermore, Brassinin enhanced the apoptotic effect with doxorubicin by activating p53. Altogether, our findings suggest that Brassinin is a new p53 regulator via induce apoptosis and inhibit the proliferation in colon cancer cells.Woon Yi ParkJi Eon ParkJi Hoon JungMDPI AGarticleBrassininp53apoptosisdoxorubicincolon cancer cellTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10036, p 10036 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brassinin p53 apoptosis doxorubicin colon cancer cell Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	Brassinin p53 apoptosis doxorubicin colon cancer cell Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Woon Yi Park Ji Eon Park Ji Hoon Jung Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
description	Brassinin derived from Chinese cabbage has been reported to act as an anti-cancer agent on prostate, liver, and colon cancer cells. However, its mechanism and impact are largely unknown in colon cancer cells. Here, we first published a report that Brassinin induces apoptosis and inhibits the survival of colon cancer cells by activating p53. We found that Brassinin induces p53 and p21 dose- and time-dependent manner in wild type of p53 colon cancer cells. Interestingly, Brassinin induces apoptosis in wild-type of p53 cancer cells, but not in null-type of p53 cancer cells dose dependently. Additionally, Brassinin induces apoptosis through L5. Furthermore, Brassinin enhanced the apoptotic effect with doxorubicin by activating p53. Altogether, our findings suggest that Brassinin is a new p53 regulator via induce apoptosis and inhibit the proliferation in colon cancer cells.
format	article
author	Woon Yi Park Ji Eon Park Ji Hoon Jung
author_facet	Woon Yi Park Ji Eon Park Ji Hoon Jung
author_sort	Woon Yi Park
title	Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
title_short	Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
title_full	Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
title_fullStr	Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
title_full_unstemmed	Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin
title_sort	apoptotic effect of brassinin via inhibition of cnot2 and activation of p53 and its combination effect with doxorubicin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0cdb50ba3ba141e1aa2be3bb7fd352a8
work_keys_str_mv	AT woonyipark apoptoticeffectofbrassininviainhibitionofcnot2andactivationofp53anditscombinationeffectwithdoxorubicin AT jieonpark apoptoticeffectofbrassininviainhibitionofcnot2andactivationofp53anditscombinationeffectwithdoxorubicin AT jihoonjung apoptoticeffectofbrassininviainhibitionofcnot2andactivationofp53anditscombinationeffectwithdoxorubicin
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Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin

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